Objective To explore the clinical value of high pressure resistance PICC  catheter in MSCT examination of patients with nephrotic syndrome. Methods A total  of 64 patients with nephrotic syndrome admitted to our hospital from August 2015 to  January 2018 were selected. All patients underwent MSCT plain and enhanced scanning  for the first time after admission. Clinical and imaging data of 64 patients were collated.  The patients were divided into high pressure resistance PICC group (n=34) and general  indwelling needle group (n=30) according to whether or not the patients were injected  with contrast medium through high pressure resistance PICC. Contrast medium was  injected into the peripheral vein of the general indwelling needle group for enhanced CT  examination. The occurrence of contrast medium exosmosis, nursing time, cost of catheter  maintenance and image quality were compared between the two groups. Results There  was no extravasation of contrast media in high pressure resistance PICC group. There was 1 case of severe extravasation and 1 case of mild extravasation in general indwelling needle  group. The rate of extravasation of contrast media in general indwelling needle group  was 6.66% (2/30). There was no significant difference in the occurrence of extravasation  of contrast media between the two groups(P＞0.05). There were significant differences  in nursing time and catheter maintenance cost between the two groups. The nursing  time of high pressure resistance PICC group was significantly lower than that of ordinary  indwelling needle group(P＜0.001). The cost of catheter maintenance in the general  indwelling needle group was significantly higher than that in high pressure resistance PICC  group(P＜0.001). The excellent and good rate of image quality score in high pressure  resistance PICC group was 97.05% (33/34), which was significantly higher than that in the  general indwelling needle group 70.00% (21/30)(P＜0.001). Conclusion The application  of high pressure resistance PICC catheter can reduce the incidence of contrast medium  exosmosis in patients with nephrotic syndrome during MSCT examination, reduce nursing  time and the cost of catheter maintenance, and improve image quality.