Head and Neck Imaging
Alterations of Gyrification-based Networks in Children with Autism Spectral Disorders*
Author：WANG Hong-wei, XU Jin-ping, HU Qing-mao,et al.
affiliation：Department of Radiology, Shenzhen Children's Hospital, Shenzhen 518000, Guangdong Province, China
PDFAbstract
Objective In this study, we investigated the topological property of the brain functional connect network between autism patients and normal control Using structural magnetic resonance imaging(sMRI), to reveal the differences between autism and normal in brain function network. Methods sMRI data were gathered from 32 autism patients and 20 normal chileren. We preprocessed the sMRI data, and then compared topological property of brain functional networks between the two groups by applying graph theoretical approaches. Results We found that the global network topology properties showed significant changes in autism. The global efficiency, local efficiency and clustering coefficient of autism are higher than those of the control group, the shortest path length was lower. In addition, the center hubs of brain functional network showed significantchanges in autism. Conclusion Our findings suggest that the integration and segregation of the brain networks were disrupted s in the autism group compared to the control group. Moreover, the abnormal distribution patterns of hubs in the brain network of ASD will help us understand brain dysfunctions in patients with autism.
【Keyword】Autism Spectrum Disorder; Structural Magnetic Resonance Imaging; Graph Theory; Cerebral Cortex Complexity; Structural Covariation
【Chart number】R338.2+5
【Document Identification Number】A
【DOI】1 0 . 3 9 6 9 / j . i s s n . 1 6 7 2 - 5131.2019.08.004
Chinese journal of CT and MRI
th17Volume， th 8 Issue
2019Year08Month
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