目的 探究氨溴索注射液经纤维支气管镜肺泡灌洗治疗大叶性肺炎的临床疗效。方法 将洛阳市妇女儿童医疗保健中 心2014年12月-2016年12月收治的200例大叶性肺炎患儿随机分为观察组(n=100)和对照组(n=100)，对照组给予止咳 化痰、抗感染等常规药物治疗，观察组在对照组基础上联合氨溴索注射液经纤维支气管镜肺泡灌洗治疗，比较两组 患儿临床症状改善时间(退热时间、咳嗽缓解时间、肺啰音消失时间)、住院时间和不良反应发生情况。结果 观察 组临床疗效总有效率(96.00%)显著高于对照组(81.00%)，差异具有统计学意义(P<0.05)；观察组退热时间、咳嗽缓 解时间、肺啰音消失时间和住院时间均显著早于对照组，差异具有统计学意义(P<0.05)；观察组不良反应发生率 (6.00%)低于对照组(12.00%)，但无统计学意义(P>0.05)。结论 氨溴索注射液经纤维支气管镜肺泡灌洗治疗有助于 改善大叶性肺炎患儿临床症状，加快患儿预后恢复，具有较高临床应用价值。

Objective To investigate the clinical effect of bronchoalveolar lavage with ambroxol injection by branchofiberoscope in the treatment of lobar pneumonia. Methods From Dec. 2014 to Dec. 2016, a total of 200 children with lobar pneumonia in Women and Children Health Care Center of Luoyang were randomly divided into observation group (n=100) and control group (n=100). Both groups were given routine drug for relieving cough, reducing sputum and inflammation, besides, the observation group was given additional bronchoalveolar lavage with ambroxol injection by branchofiberoscope. The improvement time of clinical symptoms (defervescence time, cough anesis time, pulmonary rales disappearance time), hospital stay, and adverse reactions in the two groups were compared. Results The total effective rate in the observation group was 96% which was significantly higher than that in the control group 81%, their difference was statistically significant (P<0.05). The defervescence time, cough anesis time, pulmonary rales disappearance time and hospital stay in the observation group were all significantly shorter than those in the control group, their differences were statistical significant (P<0.05). The adverse reaction rate in the observation group was 6% which was lower than that in the control group 12%, but there was no significant difference between the two groups (P>0.05). Conclusion Bronchoalveolar lavage with ambroxol injection by branchofiberoscope which has high clinical value in the treatment of lobar pneumonia, is helpful to improve the clinical symptoms and accelerate the prognosis of children.