目的 观察华蟾素胶囊配合同步放化疗治疗局部晚期食管癌的疗效与安全性。方法 将2015年1月-2016年12月入院 的84例局部晚期食管癌患者采用随机数表法分为研究组和对照组，每组42例。2组均应用放化疗治疗，研究组加用 华蟾素胶囊。对比2组临床疗效及放化疗毒副反应发生情况，评估2组治疗前后免疫功能（T淋巴细胞亚群）的差异 性。结果 ①研究组治疗总有效率高于对照组（P<0.05），放化疗毒副反应发生率则低于对照组（P<0.05）；②治 疗6w后，2组CD3+ 、CD4+ 、CD4+ /CD8+水平均较治疗前上升（P<0.05），且研究组增幅较对照组大（P<0.05）；CD8+ 水平治疗前后对比无统计学意义（P>0.05）。结论 联合使用华蟾素胶囊能有效降低放化疗毒副反应，且能积极改 善患者免疫功能，促使局部晚期食管癌临床疗效提高。

Objective To investigate the curative effect and safety of Huachansu capsule combined with concurrent chemoradiotherapy in treatment of local advance esophageal carcinoma. Methods 84 cases of local advance esophageal carcinoma in our hospital from January 2015 to December 2016 were selected and divided into observation group and control group, 42 cases in each group. Patients were all given concurrent chemoradiotherapy, and observation group plus Huachansu capsule treatment. Clinic effect, toxicity occurrence condition of chemoradiotherapy of the two groups were compared. Difference of immunological function (T-lymphocyte subsets) of the two groups before and after treatment was evaluated. Results ①Total efficiency of observation group was higher than control group (P<0.05), toxic and side effect rate of chemoradiotherapy was lower than control group (P<0.05). ②6w after treatment, CD3+ , CD4+ , CD4+ /CD8+ level of the two groups were all increased (P<0.05), growing rate of observation group was larger than control group (P<0.05), the difference of CD8+ level before and after treatment had no statistic significance (P>0.05). Conclusion Huachansu capsule combined with concurrent chemoradiotherapy can lower toxicity reaction of chemoradiotherapy, improve immunological function, and promote curative effect of local advance esophageal carcinoma.