目的 研究磁共振T1ρ在肝纤维 化进程中的变化特征，探讨T1ρ在肝纤维 化大鼠模型中的应用价值。方法 SD大鼠 65只(对照组15只，模型组50只)，模型组 采用四氯化碳诱导不同时间以获取不同程 度的肝纤维化。使用3.0T磁共振应用5个 自旋锁定时间获得T1ρ值。扫描后行肝脏 病理学检查，将影像结果与病理结果行 对照分析。结果 5只大鼠在造模过程中 死亡，60只大鼠纳入分析，肝纤维化各 期的T1ρ值在5组间整体比较差异有统计 学意义(P<0.05)。单因素方差分析，T1ρ 值在F1期和F2期之间没有差异，在其余 各期之间均有统计学差异。相关性分析 结果为T1ρ值与肝纤维化程度呈正相关 (r=0.863, P<0.05)。结论 磁共振T1ρ可 以作为一种无创、敏感的新技术用于探测 肝肝纤维进程中病理及生理改变，有助于 早期检测和定量诊断肝纤维化。

Objective To explore the value of T1 relaxation times in the rotating frame (T1ρ or T1rho) for liver fibrosis. Methods Liver fibrosis model rats (N=50) were produced by carbon tetrachloride (CCl4) injection. Five rats died during the experiment. Surviving model rats (N=45) and controls (N=15) were subjected to 3.0-T MRI and T1ρ values were determined. Liver fibrosis stage (F0–F4) was defined based on METAVIR scoring. Results T1ρ values associated positively (r=0.863,P<0.05) with severity of fibrosis stage. Conclusion T1ρ may be a new kind of noninvasive technique to show the changes of liver in pathology and histology during the progression of fibrosis.