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论著-头颈部

DSA应用于颅内复 杂动脉瘤介入杂交手术中的临床价值*

作者:杜希剑 余开湖 章凯敏 于加省

所属单位:湖北省咸宁市中心医院(同济咸宁 医院/湖北科技学院第一临床学院) 放射科 (湖北 咸宁 437100)

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摘要

目的 探讨介入杂交手术平台治 疗颅内复杂动脉瘤的效果,并观察数字 减影血管造影技术(DSA)在手术治疗前 后的评估价值。方法 采用SolitaireAB 支架辅助弹簧圈栓塞治疗颅内动脉瘤17 例(共23个动脉瘤),同时比较2D数字减 影血管造影技术(2D-DSA)、3D数字减影 血管造影技术(3D-DSA)在颅内动脉瘤检 出率方面的差异。结果 17例病理证实 为颅内动脉瘤患者中2D-DSA共检出16 例,1例微小血泡样宽颈动脉瘤因病灶 太小漏诊,准确率为94.12%,3D-DSA全 部检出,准确率达100.0%,但两种检测 方式比较差异无统计学意义(t=1.030, P=0.310)。15例宽颈动脉瘤术中达到致 密栓塞;2例未破裂颈内动脉巨大宽颈动 脉瘤予以较疏松填塞。1例双侧大脑中动 脉宽颈动脉瘤患者因术前出血量大,栓 塞治疗后行开颅清除血肿、去骨瓣减压 术。全组无死亡病例。术后随访3-30个 月,16例恢复工作,1例呈迁延性昏迷状 态(治疗3个月)。复查DSA16例动脉瘤消 失,1例疏松填塞的巨大颈内动脉宽颈动 脉瘤患者,瘤腔仍有血流灌注,但动脉 瘤未增大。结论 支架辅助弹簧圈栓塞技 术能够有效提髙颅内复杂宽颈动脉瘤栓 塞治疗的成功率,同时可有效防止再出 血,提髙复杂动脉瘤的治愈率,期间应 用DSA技术可确保治疗安全性,并对预后 做出可靠判断。

Objective To investigate the effects of interventional hybrid operation in the treatment of intracranial complex aneurysms and to observe the evaluation value of digital subtraction angiography (DSA) before and after surgical treatment. Methods 17 patients (23 aneurysms) with intracranial aneurysms were treated with SolitaireAB stent assisted coil embolization. The differences in the detection rate of intracranial aneurysms between 2D digital subtraction angiography (2D-DSA) and 3D digital subtraction angiography (3D-DSA) were compared. Results Among the 17 patients with pathologically confirmed intracranial aneurysms, 16 patients were detected by 2D-DSA. 1 case of small bleeding blister like wide carotid aneurysm was missed diagnosed because the lesion was too small and the accuracy rate was 94.12%. All were detected by 3D-DSA and the accuracy rate was 100.0%. However, there was no significant difference between the two detection methods (t=1.030, P=0.310). 15 cases of wide carotid aneurysms reached tight embolization during operation; 2 patients with large wide carotid aneurysms without ruptured internal carotid artery were given relatively looser packing. 1 patient with wide carotid aneurysm in bilateral middle cerebral artery was treated with craniotomy for removing hematoma and decompressive craniectomy after embolotherapy because of preoperative massive hemorrhage. There were no deaths in the whole group. The patients were followed up for 3-30 months after operation. 16 patients returned to work and 1 patients were in persistent coma (treated for 3 months). DSA reexamination found that 16 cases of aneurysms disappeared and there still was blood perfusion in tumor cavity of 1 patients with wide internal carotid aneurysms treated with loose packing but the aneurysm was not enlarged. Conclusion Stent assisted coil embolization technique can effectively improve the success rate of embolotherapy for treating intracranial complex wide carotid aneurysms. It can effectively prevent rebleeding and increase the cure rate of complex aneurysms. During the treatment, the application of DSA technique can ensure the safety of the treatment and make reliable judgments to prognosis.

【关键词】颅内复杂动脉瘤;DSA

【中图分类号】R743;R445.4

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2016.05.008

前言

颅内动脉瘤破裂是蛛网膜下腔出血的主要原因,致残及致死率均 高。弹簧圈栓塞是治疗颅内动脉瘤的有效方法,但颅内复杂动脉瘤形 状各异,临床治疗及诊断的难度较大。动脉瘤首次破裂出血存活率为 70%~80%,而破裂后未根治者5年内死亡率50%[1],因此早期诊断及治 疗对患者预后的改善具有重要意义,研究证实DSA具有较高的空间分辨 率及图像分辨率,可提供优势血供、血流方向等病理信息[2],但目前 对复杂动脉瘤治疗前后病理变化的评估尚缺少研究[3]。本次研究对我 院介入杂交手术平台使用SolitaireAB神经血管重塑装置(血管内自膨 式支架)辅助弹簧圈栓塞技术成功栓塞的17例复杂宽颈动脉瘤患者进行 研究,回顾性分析以上患者治疗前后DSA图像资料,现报告如下。