摘要
目的 分析MRI影像学检查在垂体 腺瘤内镜切除术中的应用价值。方法 将 我院2012年3月-2015年5月收治的36例有 明确手术指征的垂体腺瘤患者作为研究对 象,在MRI辅助下作经鼻-碟入路垂体瘤切 除术,术中继续作MRI扫描,确定是否扩 大肿瘤切除范围,对肿瘤切除已术前要求 者,结束手术,合并残留者扩大手术范 围后再作MRI扫描,重复确认直至肿瘤完 全切除,分析MRI辅助下内镜手术对垂体 腺瘤患者垂体功能的保护作用。结果 36 例垂体腺瘤患者6例肿瘤局限于鞍内,术 后MRI扫描未见肿瘤残留;30例肿瘤自鞍 旁、鞍上生长者,术中扫描9例可见肿瘤 残留,作残留肿瘤进一步切除处理,其中 7例肿瘤完全切除,2例未完全切除。扩大 切除前患者垂体腺瘤全切率为75.00%,扩 大切除后全切率高达94.44%,明显高于扩 大切除前(P<0.05);36例缓解完全缓解12 例,部分缓解20例,稳定3例,进展1例, 总缓解率为88.89%。结论 将高场强术中 MRI系统应用于垂体瘤切除术中,可提高 手术根除率,保障手术的安全性,实时并 客观评估手术结果,同时可鉴别保护垂体 周围解剖结构,避免手术误伤,降低了手 术风险。
Objective To analyze the application value of MRI imaging examination in the endoscopic resection of pituitary adenoma. Methods 36 patients with pituitary adenoma who had definite surgical indications treated in our hospital from March 2012 to May 2015 were taken as the research objects. With the assist of MRI, transnasal transsphenoidal approach resection of pituitary adenoma was performed and MRI scan was continued during surgery to determine whether to expand the scope of tumor resection. For patients who had requirements for tumor resection, the surgery was ended. After expanding the scope of surgery in patients with residual, they were scanned by MRI. Repeated confirmation was performed until complete resection of the tumor. The protective effect of MRI assisted endoscopic surgery in pituitary function of patients with pituitary adenomas. Results In the 36 cases of patients with pituitary adenomas, there were 6 cases whose tumors were confined to the saddle. Postoperative MRI scan showed no tumor residual. The intraoperative scan of 30 cases of patients whose tumors were grown beside the saddle or on the saddle showed tumor residual which were removed furtherly. 7 cases were completely resected and 2 cases were incompletely resected. The total resection rate of pituitary adenoma in patients before extended resection was 75.00%. After extended resection, the total resection rate rearched 94.44% which was significantly higher than before extended resection (P<0.05). In 36 cases, 12 cases were completely remitted and 20 cases were partially remitted, 3 cases were stable and 1 case was in progress. The total remission rate was 88.89%. Conclusion To apply high-field intraoperative MRI system in resection of pituitary adenomas can improve the eradication rate of surgery, ensure the safety of surgery, objectively evaluate the surgical results in real time and differentially protect the anatomical structures around the hypophysis at the same time. It also can avoid surgical injury and reduce the risk of surgery.
【关键词】垂体腺瘤;MRI;垂体功能;内镜
【中图分类号】R736.4
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2016.05.007
前言
垂体腺瘤为临床常见颅内肿瘤,约占颅内肿瘤的10%,不同年龄阶 段皆可发病,以中老年群体常见,发病率为1/10万左右[1]。近年来, 随着影像学诊断技术的提高,垂体腺瘤检出率也处于不断上升的趋 势,对其治疗多采用神经外科手术方案,首选内镜下经鼻-蝶入路切除 术,较多研究证实改术式对患者机体创伤小,术后恢复速度快,且并 发症发生率低[2]。但手术同样存在操作盲区,若仅依靠术前影像学资 料及术者临床经验,无法准确判断肿瘤切除程度,易造成肿瘤残留, 患者术后复发率高[3]。近期也有部分研究者表示,在高场强MRI指导 下作内镜切除术,可提高肿瘤根除率,同时保护患者垂体功能[4]。因 此,为进一步分析MRI在垂体腺瘤内镜切除术中的应用价值,我院对收 治的36例患者展开了研究,现报道如下。
中国CT和MRI杂志
第14卷, 第 5 期
2016年05月
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