目的观察乳腺癌MR动态增强扫 描(DCE-MR)的形态学及增强曲线特征，分 析动态增强参数与乳腺癌微血管密度的 关系。方法 选择乳腺癌患者30例为观察 组，乳腺良性占位患者30例为对照组， 均接受乳腺DCE-MR。观察其MR动态增强表 现及动态增强扫描-时间曲线特征，测量 和比较两组MR动态增强参数最大增强线形 斜率(SS)、增强峰值(PH)及信号强度峰值 时间(Tpeak)，并观察SS、PH及Tpeak与乳 腺癌微血管密度(MVD)的相关性。结果 乳 腺癌病灶MR动态增强显示不同程度强化， 12例呈均匀性明显强化，11例呈不均质 性明显强化，5例呈边缘性强化，3例呈 不均质性轻度强化；动态增强扫描-时间 曲线显示22例呈速升速降型，8例呈速升 平台型。观察组MR动态增强参数SS均显著 高于对照组，Tpeak显著低于对照组(均P ＜0.01)。观察组MVD均值为42.3±12.8， 显著高于对照组的12.3±3.6(P＜0.05)。 相关性分析显示，乳腺癌DCE-MR参数SS、 PH与MVD呈正相关(r=0.723，0.636)， Tpeak与MVD呈负相关(r=-0.546)(P ＜0.01)。结论 乳腺癌病灶MR动态增强具 有一定的特征性，其量化测量指标可以间 接反映MVD特征。

Objective To observe the morphology and enhancement curve of MR dynamic enhanced scan in breast cancer, Analysis of the relationship between dynamic enhanced parameters and breast cancer microvessel density. Methods 30 cases of breast cancer patients with breast cancer between January 2012 and May 2015 were selected as the observation group, 30 cases of benign breast mass were the control group, Breast enhancement scan. MR dynamic enhanced and dynamic enhanced scanning time curves of breast cancer, The maximum linear slope (SS) of MR dynamic enhancement parameters in the two groups was measured and compared, Enhanced peak value (PH) Peak time (Tpeak) and signal intensity. The correlation of SS, PH, Tpeak and microvessel density (MVD) was observed. Results The dynamic enhancement of MR in breast cancer showed different degree enhancement,12 cases showed obvious enhancement,11 cases showed obvious enhancement, 5 cases showed peripheral enhancement, 3 cases showed mild enhancement. Dynamic enhanced scanning time curve showed that 22 cases were quickly rise and fall type, 8 cases showed a rapid rise platform type. The dynamic enhancement of MR in the observation group SS (2.4±0.7)%/s vs(1.2±0.3)%/s、PH(632.3±213.2)HU vs(456.3±135.4)HU Were significantly higher than the control group, Tpeak(52.3±13.2) t/s vs(78.6±28.3)t/s Significantly lower than the control group, The difference was statistically significant (P<0.01). The mean MVD of the observation group was42.3±12.8, Significantly higher than the control group of12.3±3.6, The difference was statistically significant (P<0.05). Correlation analysis showed that SS, PH and MR in breast cancer were positively correlated with MVD (r=0.723, 0.636),Tpeak was negatively correlated with MVD (r=-0.546), And had statistical significance (P＜0.01). Conclusion The dynamic enhancement of MR in breast cancer lesions has a certain characteristic, Its quantitative measurement index can reflect the MVD.