Objective To analyze the clinical effect of targeted psychological nursing on reducing postoperative pain in patients with ENT surgery. Methods 100 cases of otolaryngology surgery were performed in our hospital from January 2016 to October 2017. The clinical data of the patients were collected and randomly divided into experimental group and control group, with 50 cases in each group. The patients in the control group were treated with routine nursing. The patients in the experimental group underwent psychological nursing intervention on the basis of routine nursing. The degree of pain, the incidence of pain and the proportion of analgesics were compared between the two groups. Results Compared with the control group, the total incidence of postoperative pain in the experimental group was 16%. The total postoperative pain rate in the experimental group was 34%. The postoperative pain rate in the experimental group was lower. Lighter, the difference between the two was statistically significant (P<0.05). Conclusion Targeted psychological care for patients undergoing ENT surgery can alleviate the pre-and post-operative adverse emotions and reduce the chance and extent of postoperative pain. Therefore, the psychological nursing intervention method can be clinically Widely used and promoted.