Objective To explore the application effect of comprehensive anti-scratch nursing program in New pediatric. Methods A total of 180 neonates who were hospitalized in our hospital from March 2018 to June 2018 were randomly divided into experimental group (integrated nursing program) and control group (conventional nursing), 90 cases in each group. Methods, the experimental group took comprehensive anti-scratch care measures on this basis. The incidence of skin scratches, the incidence of tube shedding, the pain score, the average daily sleep duration, and the fluctuation of body temperature were compared between the two groups before and after 10 days of intervention. Results The incidence of skin scratching, tube peeling, pain score and body temperature fluctuation in the experimental group were lower than those in the control group (P<0.05). The average daily sleep time of the newborn group was higher than that of the control group. (P<0.05). Conclusion Comprehensive interventions can effectively reduce the incidence of skin scratches and tube loss in newborns, reduce neonatal pain scores, improve sleep quality, and reduce body temperature fluctuations.