Objective To investigate the application value of contrast-enhanced ultrasound (CEUS), enhanced CT scan and MRI in evaluating the efficacy of interventional therapy for hepatocellular carcinoma (HCC). Methods From March 2013 to July 2015, 90 cases with HCC who received interventional therapy in our hospital were enrolled in the study. All patients were examined by CEUS before interventional therapy and they were examined by CEUS, enhanced CT and MRI scan after interventional therapy. With the results of digital subtraction angiography (DSA) as the golden standard, the detection results were compared. Results Before treatment, 90 patients were examined by CEUS, and a total of 120 lesions (homogeneous enhancement in 95 lesions and inhomogeneous enhancement in 25 lesions) were detected. One month after interventional therapy, the numbers of positive, negative and uncertain lesions detected by DSA were 76, 37 and 7,by CEUS were 75, 40 and 5, by enhanced CT scan were 58, 40 and 12, and by MRI were 65, 45 and 10. The consistency of CEUS and DSA in evaluating the efficacy was better (Kappa≥0.75), while the consistency of enhanced CT scan and MRI with the results of DSA was poor (Kappa<0.40). With the results of DSA as the golden standard, the sensitivity and total coincidence rate of CEUS in the diagnosis of positive lesions were 98.68%(75/76) and 95.00% (114/120) which were higher than those of enhanced CT scan and MRI while the false negative rate [2.70% (1/37)] was significantly lower (P<0.05). Conclusion The sensitivity and coincidence rate with DSA of CEUS in the diagnosis of positive lesions after interventional therapy are higher than those of enhanced CT scan and MRI, while the false negative rate is lower.