Objective To investigate the value of MR perfusion weighted imaging (PWI) in the diagnosis of recurrence of glioma. Methods 48 patients with glioma treated in our hospital from February 2014 to January 2016 were selected and followed up by radiotherapy, then underwent routine MR and PWI examination. Results There were 30 cases of recurrence in the total 48 cases of glioma, 18 cases had radiation brain injury; the proportion of nodular enhancement forms was 76.67% and the maximum enhancement width is greater than or equal to 5 mm ratio was 80% in the recurrence group, which were significantly higher than that of radiation brain injury group (P<0.05), the ratio of map enhancement was 10%, which was significantly lower than that of the radiation brain injury group (P<0.05). The relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) in the tumor recurrence group were 2.12 (1.02-4.81) and 1.90 (4.60-0.81), respectively, and were significantly higher than those in the radiation brain injury group (P<0.05). There was no significant difference in the relative mean transit time (rMTT) between tumor recurrence and radiation brain injury group (P>0.05). Conclusion Conventional MR enhanced scan and PWI scan in the diagnosis of brain glioma recurrence has certain value, in which PWI can provide objective indicators.