Objective Comprehensive comparative analysis of MRI (magnetic resonance imaging) combined with CT and single CT in patients with cerebral infarction in the diagnosis of results, to provide scientific data for the treatment of patients with cerebral infarction. Methods In our hospital clinical data of patients with cerebral infarction in December 2014 -2015 year in December 46 cases, according to the wishes of patients were randomly divided into experimental group and control group, each group had 23 cases. The experimental group used magnetic resonance imaging (MRI) diagnosis method combined with CT, the control group using a single diagnosis method CT. Statistical analysis of the experimental group and the control group of two patients with correct diagnosis rate, sensitivity, specificity and CT images, magnetic resonance imaging images using SPSS21.0 statistical software. Results Diagnosis of the experimental group was detected in 20 cases of cerebral infarction patients, 42 infarct lesion, the correct detection rate was 86.96% (20/23), the control group diagnosis found 15 cases of cerebral infarction patients and 31 infarction lesions, the correct detection rate was 65.22% (15/23) in the experimental group, the correct diagnosis rate is much higher than that of the control group, the data, the difference has statistical significance (P<0.05). The patients in the experimental group the sensitivity and specificity were 92.3% and 82.3%, the control group, the sensitivity and specificity were 82.3% and 75.6%, the differences were statistical significance (P<005). Conclusion MRI (magnetic resonance imaging) combined with CT in the diagnosis of cerebral infarction patients is far superior to the diagnostic results of single CT.