Objective To investigate the relationship between the changes of uric acid and creatinine levels in patients with hypertensive disorder complicating pregnancy and perinatal prognosis. Methods 200 cases of pregnancy induced hypertension and normal pregnant women in our hospital from June 2014 to January 2016 were selected. All subjects were divided into disease group (58 mild cases, 62 moderate cases and 80 severe cases) and normal group, normal, low, moderate and severe PIH serum uric acid and creatinine levels and prognosis, and effects of different levels of uric acid on perinatal outcome. Results The serum uric acid and creatinine levels of the patients increased gradually with the aggravation of hypertension, and the difference was statistically significant (P<0.05). With the increase of the severity of pregnancy, the number of premature babies born in uterine intrauterine, low birth weight, uterine stillbirth and preterm labor increased gradually, and the difference was statistically significant (P<0.05). The number of negative preterm infants was significantly higher in patients with severe hypertension than in other groups, and the difference was statistically significant(P<0.05). With elevated uric acid levels, gradually decline perinatal weight, higher proportion of premature infants, uric acid levels above 364 mu mol/L premature babies, the proportion of IUGR were significantly elevated, weight decrease, the difference was statistically significant (P<0.05). Conclusion PIH serum uric acid, creatinine levels and adverse perinatal outcome were higher than normal pregnant women, and increased with aggravation; uric acid is associated with perinatal prognosis, high uric acid levels lead to adverse perinatal outcome was significantly higher than that in normal pregnant women.