Objective To investigate the influence of related facters on T2DM patients combined with osteoporosis. Methods 59 patients with T2DM aged 28-80 years old asscoicated with osteoporosis were selected, and 61T2DM patients aged 31-79 years old with normal bone mineral density as the control. The bone mineral density of all patients including lumbar spine, femoral neck were measured. The correlation analysis of gender, age, duration of diabetes, glycosylated hemoglobin, body weight index, β-CTX, PINP, VitD, BGP and BMD was performed. Results The bone mineral density of femoral neck in osteoporosis group was significantly lower than that of the control group, while PINP and BGP were significantly higher(P<0.05). In osteoporosis with T2DM groups, age and duration of diabetes showed negative correlation with femoral neck BMD(P<0.01),while glycosylated hemoglobin, body weight index, β-CTX, PINP=VitD =BGP were found no significant correlation. Conclusion Femoral neck BMD showed a significantly decline inT2DM patients with PINP and BGP elevation. Meanwhile female, older or long course in patients T2DM increased the incidence of osteoporosis. To enhance detecting BMD in T2DM is helpful to prevent the occurrence of osteoporosis to a certain extent.