Objective To study the clinical effect of endovascular interventional treatment for diabetic foot. Methods A total of 52 patients with diabetic foot in our hospital were taken as the clinical research objects, and percutaneous transluminal angioplasty ( PTA) , stent placement and other treatment measures were given to these patients. The improvement of diabetic foot in these patients after treatment were observed. Results The total effective rates of intermittent claudication, rest pain and necrotic ulcer were respectively 92.0%, 81.48% and 84.62%. The ABI and vessel diameter were (0.94±0.26) and (2.05±0.31)cm which were significantly higher than those before treatment(P<0.05), and the ABI classification was significantly better than that before treatment. Only 3 patients had hypoglycemia and 7 patients had serve postoperative pain, and the symptoms of these patients were significantly improved after symptomatic treatment, and there were no other serious complications. Conclusion Timely balloon transluminal angioplasty or endovascular sent placement which has higher safety and better clinical effect, can effectively improve the clinical symptoms and promote rehabilitation of patients with diabetic foot