Objective To study the early application of hyperbaric oxygen therapy in patients with severe craniocerebral trauma, and to give some intervention measures to explore and analyze the clinical effect. Methods 88 cases of patients were treated in our hospital from July 2016 to July 2017 who were selected as the subjects, which were randomly divided into two groups by throwing method.44 cases of patients with conventional treatment and nursing were as the control group, 44 cases of patients with early hyperbaric oxygen therapy and nursing intervention were as the observation group, the GCS scores and post - treatment effects were compared between the two groups before and after treatment. Results After treatment, the GCS score was(12.49±2.71) in the observation group, which was significantly higher than that in the control group of (10.16±2.12), the difference was statistically significant (P<0.05). After treatment, the number of ineffectors in the control group was 14 cases (31.82%), the effective number was 30 cases (68.18%), the number of ineffective in the observation group was 2 cases (4.55%), the effective number was 42 cases (95.45%), The difference were statistically significant (P<0.05). Conclusion The application of hyperbaric oxygen therapy in patients with severe craniocerebral trauma and giving some nursing measures can improve the therapeutic effect and GCS score. It is widely recommended.