Objective To explore the effect of methyltestosterone combined with mifepristone on the prognosis of of patients with perimenopausal dysfunctional uterine bleeding (FUB). Methods From January 2014 to January 2016, 104 perimenopausal FUB patients treated in our hospital were randomly divided into study group (52 cases) and control group (52 cases). Both groups were given mifepristone, beside, the study group was given additional methyltestosterone. The curative effects and remission time in the two groups were observed, the changes of endometrium and hormone levels [progesterone (P) and estradiol (E2)] were evaluated before and after treatment, and after 1 year follow-up, the recurrence rates and bone mineral density in the two groups were recorded and compared. Results After 3.5 months treatment, the total effective rate in the study group was higher than that in the control group, and the remission time in the study group was less than that in the control group (P<0.05), the levels of P and E2 and thickness of endometrium in the two groups were all decreased, and the decrease in the study group were greater than those in the control group (P<0.05), after 1 year follow-up, the recurrence rate of the study group was lower than that of control group (P<0.05), the bone mineral density of anteroposterior projection of lumbar vertebrae, femoral neck and trochanter in the study group was higher than that in the control group (P<0.05). Conclusion Methyl testosterone combined with mifepristone whose curative effect on perimenopausal FUB is more significant, has not only positive effect on reducing recurrence rate and bone loss, but also good prognosis.