Objective To investigate the nursing intervention approach on anxiety occurred in patents receiving cardiac intervention therapy in perioperative period. Methods The study included 118 patients with cardiac intervention (PCI) and combined with anxiety, were randomly divided into intervention group(59 cases) and the control group(59 cases) .Before and after receiving PCI, usual care was carried out on control group, and additional mental nursing was underwent on the intervention group. After that, the score of self-relating anxiety scale (SAS) were evaluated, compared and analyzed. Results The proportion of patients with cardiac intervention anxiety was 44.2 %, including anxiety score and education, smoking history, family history of coronary heart disease was positively correlated (P <0.05), negatively correlated with age (P<0.01). And after mental nursing, the scores of SAS, rate of postoperative infarction, angina frequency, the incidence of arrhythmia were obviously improved than usual group.(P<0.05 or 0.001).Moreover, SAS scores of intervention group measured in the 4-week after PCI were statistically significantly higher than the control group. Conclusion PCI is a kind of stress factors which could add the psychological burden of patients, and with usual care and mental nursing, the anxiety levels improve during the course of nursing.