The Effect of Atorvastatin on Carotid Vulnerable Plaques by Contrast-Enhanced Ultrasound and Routine Ultrasound*
Author：HAN Yan-ni , ZHONG Jie-yu, HUANG Zhen-li, et al.
affiliation：Department of Ultrasonography, Neurology, Shenzhen Hospital of Peking University, Shenzhen 518036, Guangdong Province, China
PDFAbstract
Objective To evaluate the effect of atorvastatin on carotid vulnerable plaques by contrast-enhanced ultrasound (CEUS) and routine ultrasound. Methods Prospective study were done on 34 patients with carotid plaques, atorvastatin(20mg/d) was given to the patients together with the treatment of primary diseases. The Effect of the medicine before and after treatment was evaluated by CEUS, routine ultrasound and plasma lipid levels. Results 34 patients totally 57 plaques completed the study, including 34 vulnerable plaques, enhanced intensity and area under curve were obviously decreased after three-month’s or six-month’s treatment (P<0.01). Plaque scores were decreased after six month’s treatment, and the thickness of plaque with iso-echo or low-echo was decreased more significantly than that with strong or mix-echo with statistical difference(P<0.01). The plasma lipid levels were significantly lower after treatment (P<0.01). Conclusion Atorvastatin is effective in the treatment of carotid vulnerable plaque. CEUS and conventional ultrasound are useful tools to assess the changes of carotid plaque after treatment, the changes of the plaque can be observed more earlier by CEUS compared to routine ultrasound.
【Keyword】 Ultrasound; Contrast Agent; Carotid Arteries; Plaque; Atorvastatin
【Chart number】R540.4+8
【Document Identification Number】A
【DOI】10.3969/j.issn.1009-3257.2016.06.002
Journal of Rare Diseases
th23Volume， th 2 Issue
2019Year11Month
Related articles
Editor email：（1）中国CT和MRI杂志：ctmri@vip.163.com；（2）罕少疾病杂志：hs1999@vip.163.com
Contact number：0755-83695203
Our address：
English
简体中文
logged in
Wechat
TouTiao