Objective To study the clinical value of evidence-based nursing in improving the prognosis and rehabilitation efficacy of patients with angina pectoris. Methods From Jan. 2015 to Feb. 2016, a total of 86 patients with angina pectoris in our hospital were taken as the clinical research objects, and they were randomly divided into observation group(43 cases) and control group(43 cases). Patients in the control group were treated with conventional nursing, and the other patients in the observation group were treated with evidence-based nursing in order to compare their rehabilitation efficacy. Results After nursing, the indexes of angina pectoris in both groups were improved than before nursing, and their differences were statistically significant (P<0.05), the indexes of angina pectoris in the observation group were better than those in the control group, and their differences were statistically significant (P<0.05), the compliance rate in the observation group was 97.67% which was higher than that in the control group 62.79%, and their difference was statistically significant (P<0.05). Conclusion Evidence-based nursing which is helpful to increase treatment compliance of patients with angina pectoris can improve patients' life quality and rehabilitation efficacy.