Objective To study in patients with hypertension in pregnancy with labetalol and Magnesium Sulfate joint treatment on the outcome of pregnancy. Methods 58 cases of patients with gestational hypertension from April 2014 -2016 year in April in our hospital, according to the order of hospitalization were randomly divided into experimental group and control group, 29 patients in each group. The patients in the control group through the treatment of patients in the experimental group by Magnesium Sulfate, Magnesium Sulfate and labetalol combined therapy, compared two groups of patients with blood pressure, mode of delivery and neonatal outcomes. Results the two groups after treatment in patients with blood pressure significantly decreased, but experimental group after treatment in patients with blood pressure lower than the control group, two groups of patients with obvious differences (P<0.05). The patients in the experimental group the natural birth rate was significantly higher than the control group. The difference between the two groups in the rate of natural childbirth was significantly (P<0.05). The experimental group of preterm birth Rate, intrauterine distress rate and the rate of neonatal asphyxia were significantly lower than those in control group. Between the two groups significant difference (P<0.05). Conclusion In patients with pregnancy induced hypertension in the labetalol and magnesium sulfate combined therapy, effectively reduces the patient's blood pressure, increase the natural delivery rate, but also improve the neonatal outcome, it is worthy of popularization and application in clinic.