Objective To study the effect of behavioral intervention combined with targeted education on medication compliance, cognitive degree and incidence of restenosis in patients with myocardial infarction after PCI operation. Methods From Sep. 2014 to Jul. 2015, a total of 92 patients with myocardial infarction in our hospital were taken as the clinical research objects, and they were randomly divided into observation group (46 cases) and control group (46 cases). Both groups were given conventional nursing, besides, the observation group accepted additional behavioral intervention combined with targeted education in order to compare their medication compliance, cognitive degree and incidence of restenosis. Results After 12 months follow-up, the success rates in both groups were 100%. 3 months after discharge, there was no significant difference in medication compliance (P>0.05); 6 and 12 months after discharge, the medication compliance in the observation group was significantly higher than that in the control group (P<0.05). The cognitive degree in the observation group was significantly higher than that in the control group, and the incidence of restenosis in the observation group was 4.35% which significantly lower than that in the control group 17.39% (P<0.05). Conclusion Behavior intervention combined with targeted education can not only significantly improve the medication compliance and cognitive degree, but also reduce the incidence of restenosis in patients with myocardial infarction after PCI operation