目的 观察同步替吉奥化疗联合三维适形放疗治疗大肠癌疗效及不良反应。方法 收集我院2014年3月-2016年3月收 治的60例大肠癌患者，随机分为观察组和对照组各30例，对照组予以单独均予以三维适形放疗治疗，观察组予以同 步替吉奥化疗联合三维适形放疗，观察两组患者近期及远期治疗效果以及放化疗不良反应的发生情况。结果 60例 患者均完成治疗，治疗结束后1月，观察组总有效率为80.0%明显高于对照组50.0%(P＜0.05)；观察组中位无病进展 时间(11.3个月)高于对照组(8.5个月)(P＜0.05)；入选患者主要发生恶心呕吐、粒细胞减少、贫血、骨髓抑制、放 射性肠炎等不良反应，均为Ⅰ-Ⅱ度，两组不良反应发生情况比较无明显差异(P＞0.05)。结论 同步替吉奥化疗联 合三维适形放疗治疗大肠癌近期疗效好，能显著延长患者生存时间，毒副反应均为Ⅲ度以下，患者尚可耐受。

Objective To observe the curative effects and adverse reactions of synchronous tegafur chemotherapy combined with three-dimensional conformal radiotherapy on colorectal cancer. Methods From Mar. 2014 to Mar. 2016, 60 patients with colorectal cancer were collected in our hospital, which were randomly divided into observation group and control group with 30 cases in each group. Both groups were given three-dimensional conformal radiotherapy, besides, the observation group was given additional synchronous tegafur chemotherapy. The short-term and longterm effects, and adverse reaction of chemotherapy in the two groups were observed and compared. Results All the patients completed treatment, and 1 month after treatment, the total effective rate in the observation group was 80.0% which was significantly higher than that in the control group 50.0% (P<0.05), the median disease-free progression time in the observation group was 11.3 months which was significantly higher than that in the control group 8.5 months (P<0.05), the main adverse reactions in the two groups were nausea and vomiting, neutropenia, anemia, bone marrow depression and radioactive enteritis, and these symptoms were all I-II degrees, but there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Synchronous tegafur chemotherapy combined with three-dimensional conformal radiotherapy which has good curative effect in the treatment of colorectal cancer, can significantly prolong the survival time of patients. Its toxic and side effects are all below Ⅲ degree, therefore, it is tolerable for patients.