目的 观察孕中期膳食抗炎指数（DII）对初产产妇孕期血清炎症标志物水平和妊娠结局的影响。方法 选取 2015年7月-2016年7月我院收治212例初产产妇为研究对象，按DII大小进行分组，DII<-5.10，纳入抗炎倾向 组；-5.10≤DII≤-2.55，为中间组；DII>-2.55，为促炎倾向组。检测孕妇空腹状态下血清基质金属蛋白酶-3 （MMP-3）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）等水平，并比较两组不良妊娠结局早产发生率。 结果 促炎倾向组较中间组、抗炎倾向组血清MMP-3、TNF-α、IL-6水平明显升高（P<0.05）；促炎倾向组较中间 组、抗炎倾向组早产发生率明显增高（P<0.05）。结论 DII指数可用于评估孕妇孕中期膳食质量及血清炎症因子水 平，通过调整饮食结构，可有效预防早产发生。

Objective To observe the effect of dietary anti-inflammatory index (DII) in the second trimester on the levels of serum inflammatory markers and the pregnancy outcomes in primiparas during pregnancy. Methods From Jul. 2015 to Jul. 2016, a total of 212 primiparas in our hospital were taken as the clinical objects, which were divided into anti-inflammatory proneness group (DII<-5.10), middle group (-5.10≤DII≤-2.55) and proinflammatory proneness group (DII>-2.55). The levels of serum matrix metalloproteinase-3 (MMP-3), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the fasting state of pregnant women were tested, and the premature birth rates in the two groups were compared. Results The levels of MMP-3, TNF-α and IL-6 in the proinflammatory proneness group were obviously higher than those in the anti-inflammatory proneness group and middle group(P<0.05). The premature birth rate in the proinflammatory proneness group was obviously higher than those in the anti-inflammatory proneness group and middle group(P<0.05). Conclusion DII index can be used to evaluate the dietary quality and the level of serum inflammatory factors in the second trimester of pregnancy, and premature birth can be effectively prevented by adjusting dietary structure.