目的 分析异性哮喘(CVA)与典型支气管哮喘(CA)患者外周血T淋巴细胞亚群的差异性。方法 将2014年6月-2016年 5月在我院治疗的哮喘患者共60例纳入研究范围，其中异性哮喘61例为CVA组，典型支气管哮喘66例为CA组，并选 取30例健康志愿人士作为正常组，观察并比较T淋巴细胞在变异性哮喘和典型支气管哮喘中的差异。结果 两组哮 喘患儿较正常组，CD3+轻微上升，CD4+ 、CD8+ 、D4+ /CD8+ 下降，其中CD4+ 、D4+ /CD8+ 水平较正常组对比差异有统计学 意义(P＜0.05)，且CVA组CD4+、D4+/CD8+水平显著高于CV组，对比差异有统计学意义(P＜0.05)；两组哮喘患儿 CD4+ CD25+ Treg、CD4+ CD25+ Foxp3+ Treg水平显著低于对照组，其中CVA组显著高于CA组，对比差异有统计学意义；两 组哮喘患儿Th1、Th1/Th2水平下降，Th2水平上升，其中CVA组Th1水平虽低于正常组，但对比无统计学意义(P＞ 0.05)，Th1、Th2均低于对照组，Th1/Th2水平高于对照组，对比差异有统计学意义(P＜0.05)。结论 外周血T淋巴 细胞亚群在CVA与CA患者的表达具显著差异性，在CVA外周血中的波动幅度低于CA患者。

Objective To analyze the difference of T lymphocyte subsets in peripheral blood of patients with cough variant asthma (CVA) and classic bronchial asthma (CA). Methods From Jun. 2014 to May 2016, a total of 60 patients with asthma in our hospital were taken as the clinical objects, which were divided into CVA group (30 patients with cough variant asthma) and CA group (30 patients with classic bronchial asthma), and another 30 healthy volunteers were selected as normal group. The differences of T lymphocyte in cough variant asthma and classic bronchial asthma were observed and compared. Results Compared with the normal group, the CD3+ in the two groups was increased slightly, the CD4+ , CD8+ and D4+ /CD8+ in the two groups were decreased, the differences in CD4+ and D4+ /CD8+ levels were statistically significant(P<0.05), the levels of CD4+ and D4+ /CD8+ in the CVA group were significantly higher than those in the CV group, and their differences were statistically significant(P<0.05). The levels of CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+ Treg in the CVA and CA groups were significantly lower than those in the normal group, and also the levels of CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+ Treg in the CA group were significantly lower than those in the CVA group, their differences were statistically significant(P<0.05). The Th1 and Th1/Th2 levels in the two groups were decreased, but the Th2 levels in the two groups were increased, and the Th1 level in the CVA group was lower than that in the normal group, but there was no significant difference (P>0.05), the levels of Th1 and Th2 in the two groups were lower than those in the control group, the level of Th1/Th2 in the two groups was higher than that in the control group, their differences were statistically significant (P<0.05). Conclusion The expression of T lymphocyte subsets in peripheral blood shows significant difference in CVA and CA patients, and the fluctuation range in CVA peripheral blood is lower than that in CA patients.