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·头颈疾病·

甘露醇治疗早期脑出血对血肿扩大及预后的影响

作者:任 杰

所属单位:河南省商丘市睢县中医院神经内科 (河南 商丘 476900)

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摘要

目的 甘露醇治疗早期脑出血降低血肿扩大发生率和及预后的影响。方法 选取2015年5月-2016年6月医院接收的80 例脑出血患者作为研究对象,根据患者应用甘露醇的时间进行分组,对照组(n=40)患者在发病6h后应用甘露醇治 疗,观察组(n=40)患者在发病6h内应用甘露醇治疗,比较两组患者治疗效果和血肿扩大发生率。结果 对照组中血 肿增大患者有9例,血肿扩大发生率为22.50%;观察组中血肿增大患者有3例,血肿扩大发生率为7.50%,观察组血 肿扩大发生率明显低于对照组,组间差异具有统计学意义(P<0.05);观察组治疗的总有效率为90.0%,对照组的 治疗总有效率为72.5%,观察组治疗总有效率明显高于对照组,组间差异具有统计学意义(P<0.05)。结论 在脑出 血早期应用甘露醇治疗,能有效提高临床治疗效果,降低血肿扩大发生率,值得临床推广。

Objective To investigate the influence of mannitol on controlling hematoma enlargement and improving prognosis in treating early cerebral hemorrhage. Methods A total of 80 cases with cerebral hemorrhage in our hospital from May 2015 to June 2016 were selected and divided into two groups, 40 cases in each group. Control group was given mannitol treatment 6h after onset and observation group was given mannitol treatment within 6h. Compare the treatment effect and hematoma enlargement rate. Results There were 9 cases of hematoma enlargement in control group, hematoma enlargement rate was 22.50%, there were 3 cases of hematoma enlargement in observation group, hematoma enlargement rate was 7.50%, hematoma enlargement rate of observation group was lower than control group, the difference was statistic significant (P<0.05), total efficiency of observation group (90.0%) was higher than control group (72.5%), the difference was statistic significant (P<0.05). Conclusion The application of mannitol in treating early cerebral hemorrhage can improve clinic effect, lower hematoma enlargement rate and is worthy of clinic application.

【关键词】脑出血;早期;甘露醇;血肿扩大;预后

【中图分类号】R74;R54

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2017.04.014

前言

脑出血给患者神经功能带来不同程度的损伤, 致残率和致死率均较高,在急性脑出血患者中血肿 扩大是导致病情加重的主要原因,临床多应用甘露 醇进行脱水、降低颅内压[1]。本次研究选取2015年5 月~2016年6月医院接收的80例脑出血患者作为研究 对象,探讨在脑出血早期应用甘露醇治疗对血肿扩大 及预后的影响,现报告如下。