简体中文

·胸部疾病·

银杏达莫注射液对急性冠脉综合征患者脂代谢、血小板聚集性 的影响

作者:赵志强 郭敬玲

所属单位:河南省辉县市公费医疗医院内一科 (河南 辉县 453600)

PDF

摘要

目的 分析急性冠脉综合征(ACS)经银杏达莫注射液治疗的效果,并探讨该药物对病患血小板聚集、脂代谢的影 响。方法 选择我院收治的90例急性冠脉综合征病患进行研究,随机分为A、B组各45例。A组给予常规西药治疗,B 组在此基础上加用银杏达莫注射液治疗,比较两组心绞痛疗效、血小板聚集率、血脂水平、不良反应。结果 ①心 绞痛改善有效率:B组为95.56%,A组为80.00%,B组有效率比A组更高,具有差异性(P<0.05);②B组治疗后的血 脂水平明显改善,与A组(均低于A组)比较有统计学意义(P<0.05);③B组经治疗后,血小板聚集率下降,低于 A组,组别间比较有差异(P<0.05);④不良反应率:B组(4.44%)与A组(2.22%)相比无差异性(P>0.05)。 结论 ACS患者采用银杏达莫注射液治疗,能缓解心绞痛症状,改善血小板聚集率以及脂代谢,值得临床推广。

Objective To analyze the effect of ginkgo dipyidamolum injection in the treatment of acute coronary syndrome (ACS), and explore its influence on lipid metabolism and platelet aggregation. Methods A total of 90 patients with acute coronary syndrome in our hospital were were taken as the clinical research objects, and they were randomly divided into A group (45 cases) and B group (45 cases). Both groups were treated with conventional western medicine, besides, the B group was given additional ginkgo dipyidamolum injection. The improvement of angina pectoris, platelet aggregation rates, lipid levels and adverse reactions in the two groups were compared. Results The effective rate of angina pectoris improvement in the B group was 95.56% which was higher than that in the A group 80.00%, and their difference was statistically significant(P<0.05). After treatment,the lipid level in the B group was obviously improved, and it was significantly lower than that in the A group(P<0.05), the platelet aggregation rate in the B group was decreased, and it was significantly lower than that in the A group (P<0.05). The adverse reaction rates in the B and A group were respectively 4.44% and 2.22%, the difference between the two groups was not statistically significant(P>0.05). Conclusion Ginkgo dipyidamolum injection can not only relieve angina symptoms in ACS patients, but also improve platelet aggregation rate and lipid metabolism. Thus, it is worthy of application in clinic.

【关键词】血小板聚集;脂代谢;ACS;银杏达莫

【中图分类号】R331.1+43

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2017.04.007

前言

ACS是包括ST段抬高急性心肌梗死、非ST段抬高 型急性心梗死以及不稳定型心绞痛的一种临床综合征 [1]。现阶段,临床认为,ACS发病与多种因素相关, 包括附壁血栓形成、内皮功能紊乱等,尽早入院治 疗,能缓解病症,提升生活质量[2]。银杏达莫注射液 能消除自由基,可促使细胞膜稳定性增强,改善有氧 代谢,使心肌耗氧量得到控制,增加冠脉供血量[3]。 为了探讨ACS病患经银杏达莫注射液治疗的效果,我 院选择了90例患者进行研究,现报道如下。