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·头颈疾病·

认知功能评估与CT成像在轻度认知障碍中的应用

作者:许伟杰1 黎 艳2 莫 新3 陈文胜1 区汝飞1 李文轩1

所属单位:1. 广东省佛山市第三人民医院放射科 2. 广东省佛山市第三人民医院老年科 3. 广东省佛山市第三人民医院神经内科 (广东 佛山 528000)

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摘要

目的 探讨认知功能评估与CT成像在轻度认知障碍中的应用。方法 采用简单智能状态检查量表(MMSE)和蒙特利尔认 知评估量表(MoCA)对50例轻度认知障碍患者(MCI组)和50例同期正常老年体检者(对照组),行认知功能评估, 进行CT成像检测并计算海马指数。结果 对照组和MCI组之间MoCA评分和MMSE评分差异具有统计学意义(P<0.05), MCI组海马指数与颞角宽度和对照组比较差异均有统计学意义(P<0.05)。结论 采用认知功能评估与CT联合检测轻 度认知障碍更加快速、准确,为临床预防与治疗提供更为客观的指标。

Objective To discuss the application of cognitive function evaluation and CT imaging in mild cognitive impairment. Methods A total of 50 patients with mild cognitive impairment (MCI group) and 50 elderly who had normal physical examination (control group) were evaluated cognitive function by Mini-mental State Examination (MMSE) and Montreal cognitive assessment (MoCA). CT imaging of each group were performed to detect and the hippocampal index was calculated. Results The difference between MoCA score and MMSE score of MCI group and control group had statistical significance (P<0.05). Compared with the control group, the scores of each cognitive domain in MCI group were decreased, which were statistically significant (P<0.05). The difference between the hippocampal index and the width of temporal horns in both groups had statistical significance (P<0.05). Conclusion To detect mild cognitive impairment, combining the evaluation of cognitive function and CT imaging is rapider and more accurate, which provides objective indicators for clinical prevention and treatment.

【关键词】认知功能评估;轻度认知障碍;CT;阿尔茨海默病

【中图分类号】R749.1+6

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2017.04.011

前言

目前普遍认为轻度认知障碍(Mild cognitive i m p a i r m e n t, M C I )是阿尔茨海默病 ( A l z h e i m e r disease,AD)AD发病前的过渡阶段,每年大约有 10~15%的MCI转变为痴呆[1]。MCI的早期诊断,可以 指导临床尽早进行治疗,在一定程度上可以减缓老年 痴呆的病程。本研究通过对MCI的认知功能评估与CT 成像进行研究,为临床早期诊断提供依据。