论著-头颈部
PET-CT在肺癌术前 诊治中的应用
作者:王 铮1 胡述提1 张 洁1 张蓉蓉2
所属单位:1.郑州大学附属医院/河南省南 阳市中心医院胸外科 (河南 南阳 473000) 2.郑州大学附属医院/河南省南阳 市中心医院急诊外科 (河南 南阳 473000)
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目的 研究PET/CT用于肺小细胞 癌(NSCLC)术前检查对患者临床分期的影 响并分析其在患者预后中的应用价值。方 法 回顾性分析2011年6月至2013年6月我 院172例NSCLC手术治疗患者临床资料, 以术后病理检查结果为金标准,分析18FFDG PET/CT对肿瘤原发病灶、周围淋巴结 及远处转移检查结果的准确性,计算原发 病灶SUVmax并分析其对患者术后远期生存 情况的影响。结果 PET/CT检查对NSCLC 原发病灶术前T分期准确率为93.60%;对 N1、N2淋巴结及远处转移术前检测灵敏 度分别为88.16%、93.10%和92.59%,特 异度为79.17%、81.57%及81.37%,准确 率为83.14%、85.47%及83.14%,一致性 Kappa值为0.663、0.697及0.537;172 例NSCLC患者原发病灶SUVmax范围为3.2- 37.1,其中位数为12.4,以SUVmax=12.4为 临界值将患者分为两组,采用Log-rank 检验显示,SUVmax≤12.4患者DFS及OS均 高于SUVmax>12.4的患者,差异有统计学 意义(χ2 =3.864、4.889,P<0.05)。结论 PET/CT用于NSCLC术前检查可提高TNM分期 准确性,同时还能利用SUVmax值评估患者 预后情况,为临床选择合理治疗方案提供 重要依据。
Objective To study the effects of PET/CT on the clinical stages of patients with non-small-cell lung cancer (NSCLC) and to analyze its application value in the prognosis of patients. Methods The clinical data of 172 patients with NSCLC surgery from June 2011 to June 2013 were retrospectively analyzed retrospectively. The results of postoperative pathological examination were used as the gold standard to analyze the accuracies of 18F-FDG PET/CT in the detection of primary tumors, peripheral lymph nodes and distant metastasis, and the SUVmax of primary lesion was calculated and its effects on postoperative long-term survival were analyzed. Results The accuracy rate of PET/CT was 93.60% in the detection of preoperative T staging of NSCLC primary lesions. The sensitivities of preoperative detection of N1, N2 lymph nodes and distant metastasis were 88.16%, 93.10% and 92.59%, and the specificities were 79.17%, 81.57% and 81.37%, and the accuracy rates were 83.14%, 85.47% and 83.14%, and the consistency Kappa values were 0.663, 0.697 and 0.537.The SUVmax range was 3.2 to 37.1 among 172 patients with NSCLC with a median of 12.4. SUVmax=12.4 was used as the critical value to divide the patients into two groups. Log-rank test showed that the DFS and OS of patients with SUVmax≤12.4 were higher than those of patients with SUVmax >12.4 (χ2 =3.864, 4.889, P<0.05). Conclusion PET/CT for preoperative examination of NSCLC can improve the accuracy of TNM staging, and can also use SUVmax value to evaluate the prognosis of patients, and it provides an important basis for clinical selection of reasonable treatment regimens.
【关键词】非小细胞肺癌;PET/CT;原发 病灶;淋巴结转移;远处转 移;预后
【中图分类号】R814.42;R735.2
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2019.03.004
前言
肺癌(lung cancer)是全球范围内发病率和死亡率居于首位的 恶性肿瘤,根据组织学可分为非小细胞肺癌(non-small cell lung carcinoma,NSCLC)及小细胞肺癌(small cell lung carcinoma, SCLC)两类,其中前者包括鳞癌、腺癌及大细胞癌等,在全部肺癌中 占比约为83%[1-3]。早期NSCLC首选治疗方案为手术切除,精确分期对 指导肺癌规范化治疗和手术方案选择均具有重要指导意义,病理检查 是现阶段肺癌诊断金标准,但作为有创检查、不宜常规开展,X线、 CT及MRI等影像学检查对纵隔纵膈淋巴结诊断价值又较为有限,正电 子发射断层扫描/计算机体层成像(positron emission tomography/ computed tomography,PET/CT)兼具解剖结构和代谢功能两种图像优 势,对判断肿瘤组织形态特征和生物学行为均具有良好参考价值,因 而在恶性肿瘤诊断和治疗中的应用范围得到逐渐推广[4-5]。本文主要回 顾性分析PET/CT检查用于NSCLC患者术前诊断、临床分期和术后生存评 估的价值,为推广PET/CT在肺癌诊断和治疗中的应用提供参考依据。
中国CT和MRI杂志
第17卷, 第 3 期
2019年03月
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