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24h动态心电图联合 64MDCT冠状动脉成 像诊断隐匿性冠心 病的准确性分析

作者:纪焕文1 肖新广2

所属单位:1.郑州大学附属郑州市中心医院心 内科 (河南 郑州 450000) 2.郑州大学附属郑州市中心医院影 像科 (河南 郑州 450000)

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摘要

目 的 分析24h动态心电图 (Holter)联合64排螺旋电子计算机断层 扫描(MDCT)冠状动脉成像诊断隐匿性冠 心病(CHD)的准确性。方法 选取我院68 例疑似隐匿性CHD患者为研究对象,对患 者分别行24h Holter、64 MDCT冠状动脉 成像及冠状动脉造影(CAG)检查,以CAG 为诊断隐匿性CHD金标准,分析比较24h Holter、64 MDCT冠状动脉成像及其联合 诊断对隐匿性CHD的诊断价值。结果 共68 例患者中60例确诊为隐匿性CHD,其481段 冠状动脉中冠状动脉管腔正常264段,轻 度病变124段,中度病变67段,重度病变 26段。64 MDCT冠状动脉成像诊断准确60 例(88.24%),且对冠状动脉管腔狭窄程度 诊断准确187段(86.18%);24h Holter诊 断准确55例(80.88%);联合诊断诊断准确 66例(97.06%)。联合诊断的灵敏度明显高 于24h Holter(P<0.05),准确率明显高 于64 MDCT冠状动脉成像及24h Holter(P <0.05);而64 MDCT冠状动脉成像及24h Holter灵敏度、准确率和3种诊断方式的 特异度、阳性预测值、阴性预测值比较, 差异均无统计学意义(P>0.05)。结论 24h Holter、64 MDCT冠状动脉成像联合 可提高隐匿性CHD的诊断准确性,具有较 好的应用前景。

Objective To analyze the accuracy of 24h dynamic electrocardiogram (Holter) combined with 64-slice spiral computed tomography (MDCT) coronary angiography in the diagnosis of latent coronary heart disease (CHD). Methods A total of 68 cases of suspected latent CHD in our hospital were selected for the study, and the patients were given 24h Holter, 64 MDCT coronary angiography and coronary angiography (CAG). Take CAG was the gold standard for the diagnosis of latent CHD, and the diagnostic values of 24h Holter, 64 MDCT coronary angiography and the combined diagnosis for latent CHD were analyzed and compared. Results Of the 68 patients, 60 cases were diagnosed as latent CHD. Among the 481 coronary arteries, 264 were normal coronary lumens, 124 were mild lesions, 67 were moderate lesions, and 26 were severe lesions. 64 MDCT coronary angiography was accurate in 60 cases (88.24%), and the diagnosis of coronary stenosis was accurate in 187 segments (86.18%). 24h Holter was accurate in 55 cases (80.88%), and the combined diagnosis was accurate in 66 cases (97.06%). The sensitivity of combined diagnosis was significantly higher than that of 24h Holter (P<0.05), and the accuracy was significantly higher than that of 64 MDCT coronary angiography and 24h Holter (P<0.05). There were no significant differences in the sensitivity and accuracy between 64 MDCT coronary angiography and 24h Holter and in the specificity, positive predictive value and negative predictive value among the three diagnostic methods (P>0.05). Conclusion 24h Holter combined with 64 MDCT coronary angiography can improve the diagnostic accuracy of latent CHD, and has a good application prospect.

【关键词】隐匿性冠心病;MDCT;冠状动 脉成像;24h动态心电图

【中图分类号】R541

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2019.03.006

前言

隐匿性冠心病(CHD)为临床常见CHD类型,患者多无胸痛、胸闷等 主观症状,但伴有冠脉病变,早期诊断困难,且隐匿性CHD又可进展为 心绞痛或心肌梗死,诊治延误可造成严重后果[1]。因此,对CHD高危人 群进行相关检查,以及时发现隐匿性CHD非常重要。隐匿性CHD的诊断 金标准为冠状动脉造影(CAG),但CAG为一种有创检查方式,应用于无 症状的隐匿性CHD患者中,存在接受度不高等缺点[2]。故寻找诊断价值 较高的无创检查方法有其必要性。24h动态心电图(Holter)及64排螺旋 电子计算机断层扫描(MDCT)均能作为辅助诊断CHD的常见手段,但关于 二者联合诊断的研究却较为少见。基于此,本研究选取我院68例疑似 隐匿性CHD患者为研究对象,以评估上述两种无创检查方式的联合诊断 价值,现报告如下。