目的 探究正电子发射-计算机断 层扫描显像(PET-CT)在弥漫大B细胞淋巴 瘤(DLBCL)诊治中的应用。方法 回顾性分 析86例DLBCL患者临床资料，所有患者均 于治疗前后接受PET-CT检查，分析PET-CT 对DLBCL分期的诊断价值及治疗前后患者 PET-CT影像特征；根据治疗效果分为完 全缓解组(CR组，n=35)、部分缓解组(PR 组，n=33)、疾病稳定组(SD组，n=8)、进 展组(PD组，n=10)，比较四组患者治疗前 后标准化摄取最大值变化率(ΔSUVmax)、 病灶直径水平差异。结果 PET-CT对DLBCL 分期诊断准确率为91.9%(79/86)。治疗 前后患者PET-CT影像特征均有不同程度变 化，四组ΔSUVmax水平比较差异有统计学 意义(P＜0.05)；四组病灶直径比较差异 无统计学意义(P＞0.05)。结论 PET-CT在 DLBCL诊治过程中可提供较可靠的影像学 依据，有较高应用价值。

Objective To explore the application of positron emission tomographycomputed tomography (PET-CT) in the diagnosis and treatment of diffuse large B-cell lymphoma (DLBCL). Methods The clinical data of 86 DLBCL patients were analyzed retrospectively. All patients were given PET-CT examination before and after treatment, and the diagnostic value of PET-CT in the DLBCL staging and the PET-CT imaging features were analyzed. According to the treatment effect, the patients were divided into complete remission group (CR group, n=35), partial remission group (PR group, n=33), disease stabilization group (SD group, n=8) and progression group (PD group, n=10). The maximum change rate of standardized uptake value (ΔSUVmax) and the lesion diameter were compared before and after treatment among four groups. Results The diagnostic accuracy of PET-CT for DLBCL staging was 91.9% (79/86). The PET-CT imaging features were changed in different degrees before and after treatment, and there were significant differences in the ΔSUVmax among four groups (P<0.05). There was no significant difference in lesion diameter among four groups (P>0.05). Conclusion PETCT can provide reliable imaging basis in the diagnosis and treatment of DLBCL, and has high clinical value.