摘要
目的 MRI、CT及X线在诊断多发 性骨髓瘤(MM)中的应用比较。方法 选择 2017年1月到2018年1月到医院就诊MM患者 80例,所有患者均进行MRI、CT、X线检 查。统计MRI、CT、X线三种检查方式的影 像特征,统计MRI、CT、X线三种检查方式 诊断效能,及对不同部位骨损害病灶检出 率。结果 X线检查中80例患者病变类型最 多为骨质破坏型,占比80%;CT检查中80 例患者病变类型最多为骨质破坏型,占 比87.50%;MRI检查中80例患者病变类型 最多为局灶型,占比52.50%;MRI诊断准 确率、灵敏度均高于CT、X线,差异有统 计学意义(P<0.05);MRI、CT、X线三种 检查方法特异度差异无统计学意义(P> 0.05);MRI检查在颅骨病灶检出率高于CT 及X线,差异有统计学意义(P<0.05); MRI、CT、X线三种检查方式在病灶位于脊 椎、盆骨、肋骨及四肢处检出率差异无统 计学意义(P>0.05)。结论 MRI对MM诊断 准确率、灵敏度均高于CT、X线,并在颅 骨处病灶检查更有优势。
Objective To compare the MRI, CT and X-ray in the diagnosis of multiple myeloma (MM). Methods A total of 80 cases of MM who were admitted to the hospital from January 2017 to January 2018 were selected and given MRI, CT, and X-ray examinations. The imaging features and the diagnostic efficacy of MRI, CT and X-ray were analyzed. The detection rates of bone lesions in different sites were recorded by MRI, CT and X-ray. Results Among 80 patients, the most common type of lesion is bone destruction in X-ray, accounting for 80%. In CT examination, the most common lesion was bone destruction, accounting for 87.50%. In MRI, the most common lesion type was multifocal type, accounting for 52.50%. The accuracy and sensitivity of MRI diagnosis were higher than those of CT and X-ray(P<0.05). There was no statistical significance in the specificity of MRI, CT and X-ray (P>0.05). The detection rate of skull lesions by MRI was higher than that by CT and X-ray (P<0.05). There was no significant difference in the detection rates of lesions in spine, pelvis, ribs and extremities by MRI, CT and X-ray (P>0.05). Conclusion The accuracy and sensitivity of MRI for MM diagnosis are higher than those of CT and X-ray, and MRI is more advantageous in the examination of lesions in skull.
【关键词】磁共振成像;电子计算机断层 扫描;X射线;多发性骨髓 瘤;诊断
【中图分类号】R73;R81
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2019.03.038
前言
多发性骨髓瘤(MM)属于恶性浆细胞疾病,其肿瘤细胞来自骨髓中 浆细胞[1]。由于浆细胞是B淋巴细胞发育最终阶段,MM可归属于B细胞淋 巴瘤。MM患者骨髓中浆细胞出现异常增生并伴有过度生成单克隆免疫 球蛋白,通常合并贫血、肾脏损害等疾病[2]。MM常见于40岁以上男性 人群,由于患者体内正常免疫蛋白生成受到抑制,更容易出现细菌感 染。MM病情发展缓慢,早期临床无明显病症,误诊率较高,后期临床 可表现为骨痛、感染、出血等[3]。对于MM患者,只有出现症状才开始治 疗,但有研究显示超过80%无症状MM高危患者会在2年内发展成MM。因 此,早期诊断干预十分必要。MM治疗方式包括一般对症治疗、化疗、 放疗及移植造血干细胞,其中一般对症治疗包括输注红细胞、血液透 析、抗感染治疗等[4]。X线、MRI、CT是常用的影像学检查方法[5],本研 究采用以上三种方法诊断MM,旨在比较三种检查方法的诊断效能。
中国CT和MRI杂志
第17卷, 第 3 期
2019年03月
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