论著-头颈部
18F-FDG PET-CT联合 血清SCC-Ag检测对 宫颈癌盆腔淋巴结 转移的诊断价值*
作者:张冬雅 郭红军
所属单位:郑州大学第一附属医院妇科 (河南 郑州 450052)
PDF摘要
目的 探讨18氟代脱氧葡萄糖 (18F-FDG)PET-CT联合血清鳞状上皮细胞 癌抗原(SCC-Ag)对检测宫颈癌盆腔淋巴 结转移的诊断价值。方法 选取2017年1 月-2017年9月本院收治的56例宫颈癌术 后患者为研究对象,纳入患者分别行18FFDG PET-CT、血清SCC-Ag检查以及18FFDG PET-CT联合血清SCC-Ag检测,并以 术后病理结果或随诊(随访时间≥6个月) 结果为金标准,评估三者对宫颈癌盆腔 淋巴结转移的诊断价值。结果 18F-FDG PET-CT联合血清SCC-Ag诊断宫颈癌盆腔 淋巴结转移的灵敏度、特异度、准确度 分别为91.67%、85.00%、89.29%,较18FFDG PET-CT诊断或血清SCC-Ag检测宫颈癌 盆腔淋巴结转移的灵敏度、特异度、准 确度(69.44%/75.00%、80.00%/65.00%、 73.21%/71.43%)高。结论 18F-FDG PET-CT 联合血清SCC-Ag检测对宫颈癌盆腔淋巴结 转移的诊断有较高灵敏度、特异度和准确 度,有一定临床推广应用优势。
Objective To investigate the value of 18 fluorodeoxyglucose (18F-FDG) PETCT combined with serum squamous cell carcinoma antigen (SCC-Ag) in diagnosing pelvic lymph node metastasis of cervical cancer. Methods A total of 56 patients with cervical cancer who were treated in the hospital from January to September 2017 were selected as the subjects. All patients underwent 18F-FDG PET-CT, serum SCC-Ag examination and 18F-FDG PET-CT combined with serum SCC-Ag detection. With postoperative pathological results or follow-up (follow-up time was 6 months) results as the golden standard, the value of the three in the diagnosis of pelvic lymph node metastasis of cervical cancer was evaluated. Results The sensitivity, specificity and accuracy of 18FFDG PET-CT combined with serum SCC-Ag in the diagnosis of pelvic lymph node metastasis of cervical cancer (91.67%, 85%, 89.29%) were higher than those of 18FFDG PET-CT or serum SCC-Ag (69.44%/75.00%, 80.00%/65.00%, 73.21%/71.43%). Conclusion The sensitivity, specificity and accuracy of 18F-FDG PET-CT combined with serum SCC-Ag detection are high in the diagnosis of pelvic lymph node metastasis of cervical cancer.
【关键词】宫颈癌;盆腔淋巴结转移; 18F-FDG PET-CT;SCC-Ag; 诊断
【中图分类号】R737.33;R817.4;R814.42
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2019.03.032
前言
宫颈癌为女性患者常见恶性肿瘤,其患病率仅次于乳腺癌,鳞状 细胞癌是宫颈癌组织学分型中最为常见类型,近年来其患病率和死亡 率较高,现代医学研究表明宫颈癌复发、转移率较高,而尽早准确地 诊断复发转移病灶并及时治疗可在一定程度上改善宫颈癌患者预后, 对提高患者生存率以及生活质量有着重要临床意义[1]。目前血清肿瘤 标志物在宫颈癌早期诊断中逐渐被应用,恶性肿瘤有其特殊基因表达 产物,其中鳞状上皮细胞癌抗原(SCC-Ag)是宫颈癌最常见的肿瘤标志 物[2],有学者研究表明血清SCC-Ag水平与宫颈癌转移、浸润程度存在 一定相关性,对宫颈癌复发有一定预测意义[3]。PET-CT可通过注射示 踪剂对肿瘤一般生理以及生化特点进行反映,而18氟代脱氧葡萄糖 ( 18F-FDG)为目前临床上最常使用的示踪剂[4],PET-CT可较好地反映肿 瘤的解剖、代谢信息,其在宫颈癌复发转移判断中也有一定应用价 值[5]。但目前有关18F-FDG PET-CT联合血清SCC-Ag检测对宫颈癌盆腔淋 巴结转移的诊断应用研究并不多见,为此本文展开临床对照性研究, 结果如下。
中国CT和MRI杂志
第17卷, 第 3 期
2019年03月
相关文章