目的 分析3.0T磁共振动态增强 (DCE-MRI)扫描定量参数对肺癌的诊断 价值。方法 对我院近两年(2016年1月至 2018年1月)呼吸内科经病理证实为肺癌 的89例患者均行磁共振(MRI)常规检查及 DCE-MRI检查，比较不同类型肺癌及周围 正常胸壁组织的各定量指标[容量运转参 数(Ktrans)、速率常数(Kep)血管外细胞外 容积比(Ve)]，分析DCE-MRI不同定量参数 对肺癌的诊断效能，并确定最佳阈值。 结果 (1)病理结果显示89例肺癌患者中 央型肺癌41例、周围型肺癌48例；鳞癌 25例、腺癌49例、小细胞癌15例，所有 患者均为单发病灶；(2)肺癌病灶定量参 数Ktrans、Kep、Ve均显著高于周围正常胸壁 组织(P<0.05)，各癌灶各定量参数Ktrans、 Kep、Ve差异显著(P<0.05)，非小细胞肺癌 (鳞癌及腺癌)定量参数均显著高于小细胞 癌(P均<0.05)，腺癌定量参数均显著高 于鳞癌及小细胞癌(P<0.05)(3)定量参数 Ktrans、Kep、Ve对肺癌的诊断具有较高的临 床价值，ROC曲线下曲线下面积(AUC)分别 为0.816、0.768、0.821，其敏感度分别 为71.5%、68.7%、68.4%，特异度分别为 85.2%、82.6%、97.2%。结论 3.0T磁共振 动态增强扫描定量参数可较准确诊断肺癌 并测定不同病理类型肺癌，具有较高的临 床诊断价值，可为临床肺癌的诊断提供影 像依据。

Objective To analyze the diagnostic value of quantitative parameters of 3.0T dynamic contrast-enhancement magnetic resonance imaging (DCE-MRI) scanning for lung cancer. Methods A total of 89 patients which confirmed of lung cancer pathologically for the past two years (January 2016 to January 2018) were gin magnetic resonance imaging (MRI) routine examination and DCE-MRI. The quantitative indicators [capacity transfer constant (Ktrans), rate constant (Kep), extravascular extracellular volume ratio (Ve)] were compared among different types of lung cancer and surrounding normal chest wall tissue. And the diagnostic efficacy of different quantitative parameters of DCE-MRI for lung cancer was analyzed, and the optimal threshold was determined. Results The pathological results showed that there were 41 cases of central lung cancer, 48 cases of peripheral lung cancer, 25 cases of squamous cell carcinoma, 49 cases of adenocarcinoma and 15 cases of small cell carcinoma among 89 cases of patients with lung cancer, and all patients were single lesions. Quantitative parameters Ktrans, Kep and Ve of lung cancer lesions were significantly higher than those of surrounding normal chest wall tissue (P<0.05). There were significant differences in quantitative parameters Ktrans, Kep and Ve of each lesion (P<0.05), and the quantitative parameters of non-small cell lung cancer (squamous cell carcinoma and adenocarcinoma) were significantly higher than those of small cell carcinoma (all P<0.05), and the quantitative parameters of adenocarcinoma were significantly higher than those of squamous cell carcinoma and small cell carcinoma (P<0.05). Quantitative parameters Ktrans, Kep and Ve had high clinical value in the diagnosis of lung cancer, the areas under the ROC curve (AUC) were 0.816, 0.768 and 0.821 respectively, and the sensitivities were 71.5%, 68.7%, and 68.4% respectively, and the specificities were 85.2%, 82.6%, and 97.2% respectively. Conclusion Quantitative parameters of 3.0T dynamic contrast-enhancement magnetic resonance imaging scanning can diagnose lung cancer and determine different pathological types of lung cancer accurately. And it has high clinical diagnostic value and can provide imaging basis for the diagnosis of clinical lung cancer.