论著-头颈部
3.0T磁共振多期增 强扫描对胰腺癌术 前诊断及手术可切 除性评估中的价值*
作者:刘 华1 郝 凯2 翟冬枝1
所属单位:1.郑州大学第二附属医院放射科 (河南 郑州 450000) 2.郑州人民医院 (河南 郑州 450000)
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目的 探究3.0T磁共振(MRI)多 期增强扫描对胰腺癌术前诊断及手术可 切除性评估中的价值。方法 收集2017年 2月-2018年2月经手术病理证实为胰腺癌 的41例患者的临床资料,均于术前2周内 行3.0T MRI常规平扫及多期增强扫描, 回顾性分析患者的MRI征象,并根据病灶 情况、局部侵犯、转移、血管受累情况评 估手术可切除性。结果 MRI常规平扫中发 现31例胰腺肿块,动态增强扫描发现37例 胰腺肿块,二者检出率比较差异无统计学 意义(χ2 =3.101,P>0.05),但与强化正 常组织比较更明显,可在一定程度上提 高肿块检出率;MRI诊断准确率87.80%, 误诊率12.20%;LAVA动态增强MRI评估 手术可切除性的敏感度、特异度、准确 度为81.82%、93.33%、90.24%,Kappa值 =0.752,MRI术前评估结果与手术结果 一致性较好。结论 对胰腺癌患者术前行 3.0T MRI多期增强扫描不仅可提高肿瘤病 灶及转移灶的检出率,准确评估胰周侵犯 及胰周血管受累情况,还可有效评估手术 可切除性,为临床治疗方案的制定提供重 要参考。
Objective To explore the value of 3.0T magnetic resonance imaging (MRI) multi-phase enhanced scan in the evaluation of preoperative diagnosis and surgical resectability of pancreatic cancer. Methods The clinical data of 41 patients with pancreatic cancer confirmed by surgical pathology from February 2017 to February 2018 were collected. All patients were given 3.0T MRI plain scan and multi-phase enhanced scan within 2 weeks before operation. The MRI signs were analyzed retrospectively, and the surgical resectability was evaluated according to the lesion condition, local invasion, metastasis and vascular involvement. Results There were 31 cases of pancreatic masses found by routine MRI scan, and 37 cases of pancreatic masses revealed by dynamic enhanced scan, and there was no significant difference in the detection rate between the two methods (χ2 =3.101, P>0.05), but it was obvious higher than that of normal enhanced tissues, and it could improve the detection rate of tumors to a certain extent. The diagnostic accuracy and the misdiagnosis rate of MRI were 87.80% and 12.20%. The sensitivity, specificity and accuracy of LAVA dynamic enhanced MRI in assessment of surgical resectability were 81.82%, 93.33% and 90.24%, and the Kappa value was 0.752, and preoperative assessment of MRI was consistent with the surgical outcomes. Conclusion Preoperative 3.0T MRI multi-phase enhanced scan for patients with pancreatic cancer can not only increase the detection rate of tumor lesions and metastases, but also accurately assess peripancreatic invasion and peripancreatic vascular involvement, and it can effectively evaluate the surgical resectability, and it provides important references for the establishment of clinical treatment regimens.
【关键词】 磁共振多期增强扫描;胰腺 癌;术前诊断;手术可切除性
【中图分类号】 R735.9;R445.2
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2019.03.028
前言
胰腺癌多起源于腺管上皮的导管腺癌,具高侵袭性特征,恶性程 度较高,据资料显示其发病率正逐年增长,多数患者早期症状隐匿, 仅出现食欲减退、乏困、恶心脂肪泻等不典型症状,待出现心窝部疼 痛等明显症状就诊时,患者多已经处于病情晚期,失去手术切除的机 会,治疗难度大大增加[1-2]。因此早期诊断及术前准确评估手术可切除 性至关重要,可为患者争取宝贵的手术机会,减少不必需的探查。多 项研究指出[3-4],术前影像学检查判定胰腺癌可切除性对患者的预后有 重要意义。随着近年来3.0T MRI成像技术的不断改进和发展,尤其是 脂肪抑制及快速成像脉冲序列等技术的广泛开展,其在胰腺癌术前评 估中的价值已得到肯定[5]。但关于3.0T MRI多期增强扫描的研究少有涉 及,本研究旨在探究3.0T MRI多期增强扫描对胰腺癌术前诊断及手术 可切除性评估中的价值,报道如下。
中国CT和MRI杂志
第17卷, 第 3 期
2019年03月
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