论著-头颈部
CT征象和肝细胞癌 患者临床病理特征 与血管内皮生长因 子的相关性研究*
作者:陈雅菲1 雷 雷2
所属单位:1.河南省新乡市中心医院消化科 (河南 新乡 453000) 2.河南省人民医院消化内科 (河南 郑州 450000)
PDF摘要
目的 探讨CT 征象与肝细胞癌 患者临床病理特征、血管内皮生长因子 的相关性。方法 选取2014年10月到2016 年1月在我院接受治疗的肝细胞癌患者98 例,术前行CT增强扫描,对患者的肿瘤 长径、门静脉癌栓、肝硬化、肝淋巴结 肿大情况进行统计,并与术后病理结果进 行对比,同时检测血管内皮生长因子指标 特征并与CT征象结果进行对比,分析其与 CT检查结果的相关性。结果 肿瘤长径大 于5厘米和门静脉癌栓患者例数比较不具 有统计差异(P>0.05),肝硬化和淋巴结患 者检查结果两者比较差异具有统计学意义 (P<0.05); CT表现与VEGF表达相关的有 瘤体边缘清晰度、瘤体坏死状况及有无静 脉癌栓(P<0.05),CT表现瘤体直径、瘤体 有无供血动脉与VEGF表达无关(P>0.05)。 结论 CT可以较为准确的反应肝细胞癌患 者基本状况,但仍然存在不足之处,VEGF 的表达与CT有密切关系。
Objective The correlation between CT findings and clinical pathological characteristics and vascular endothelial growth factor in hepatocellular carcinoma patients. Methods 98 cases of patients with hepatocellular carcinoma from October 2014 to January 2016 in our hospital were selected, preoperative CT scans of patients with tumor size, liver cirrhosis, venous invasion, lymph node enlargement was analyzed, The results were compared with the pathological results after operation, and the vascular endothelial growth factor (VEGF) was detected and compared with the CT findings, and the correlation between the VEGF and CT findings was analyzed. Results Tumor diameter greater than 5 cm and the number of patients with carcinoma of PVTT comparison does not have statistical differences (P>0.05), cirrhosis of the liver and lymph nodes in patients with test results there was significant difference between them (P<0.05), the expression of CT and VEGF are related to the tumor edge definition, tumor necrosis, and there is no PVTT (P<0.05), CT manifestations of tumor diameter, tumor free arteries and the expression of VEGF (P>0.05). Conclusion CT can be a more accurate response to the basic situation of patients with hepatocellular carcinoma, but there are still some deficiencies, VEGF expression and CT have a greater relationship.
【关键词】CT;肝细胞癌;病理特征;血 管内皮生长因子
【中图分类号】R735.7
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2018.05.029
前言
肝细胞癌(Hepatocellular carcinoma cancer HCC)的死亡率在消 化系统恶性肿瘤中列第3位[1]。因此目前对肝细胞癌的检测及治疗显得 尤为重要。肝癌门静脉栓的形成是影响肝癌预后的重要因素,临床发 生率高达60%到90%。CT平扫和增强扫描时目前两种最常见的术前检查 方法,其中增强扫描准确率较高[2-3],因此本研究采用CT增强扫描。血 管内皮生长因子(vascular endothelial growth factor,VEGF)诱导 肿瘤血管的形成,在很多肿瘤中有异常表达,肝癌肿瘤组织中VEGF表 达报道较多[4-5]。本研究将对CT 征象与肝细胞癌患者临床病理特征、 血管内皮生长因子的相关性进行探讨。
中国CT和MRI杂志
第16卷, 第 5 期
2018年05月
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