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磁共振DTI技术在评估脑梗死患者运动功能康复治疗效果中的研究

作者:郭龙军1 陈忠伟2 滕佳岐1 王 娟1 冯国洋1

所属单位:1.首都医科大学附属北京康复医院(北京 100144) 2.北京市丰台区南苑医院(北京 100054)

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摘要

目的 探讨磁共振弥散张量成 像(DTI)在评估脑梗死患者运动功能康 复治疗效果中的应用价值。方法 医院 36例慢性脑梗死患者运动功能康复治疗 前后均行磁共振成像和DTI检查,处理 图像数据获得各向异性分数(FA)伪彩 图,行双侧皮质脊髓束(CST)重建,对 健侧和患侧相关数据进行统计分析。 结果 本组36例患者中,2级15例,占 41.67%;3级21例,占58.33%;将15例2 级作为A组,21例3级作为B组;A组康复 FA值为(0.612±0.039)显著高于B组;2 组康复后均显著下降,与康复前相比, 差异显著(P<0.05);A组康复后FA值为 (0.556±0.064)显著高于B组,具有统 计学意义(P<0.05);康复前A组FudlMeyer评分为(57.264±5.821)分显著高 于B组,康复后A组Fudl-Meyer评分为 (85.162±9.861)分显著高于B组,差异 显著(P<0.05);康复治疗前后CST FA值 下降百分数与Fudl-Meyer评分上升百分 数呈负相关关系。结论 磁共振DTI技术 可根据CST受损程度评估肢体运动康复训 练效果。

Objective To investigate the application value of magnetic resonance diffusion tensor imaging (DTI) in evaluating the effect of motor function rehabilitation in patients with cerebral infarction. Methods Magnetic resonance imaging (MRI) and DTI examination were performed in 36 cases of patients with chronic cerebral infarction in the hospital before and after the motor function rehabilitation. The image data were processed to obtain fractional anisotropy (FA) pseudo color pictures. The bilateral corticospinal tract (CST) reconstruction was performed and the related data of contralateral healthy side and diseased side were statistically analyzed. Results Among the 36 patients, 15 cases were in grade 2, accounting for 41.67% and 21 cases in grade 3, accounting for 58.33%. 15 cases in grade 2 were taken as group A while 21 cases in grade 3 as group B. The rehabilitation FA value in group A was (0.612±0.039) which was significantly higher than that in group B. After recovery, that in the two groups decreased significantly. Compared with that before recovery, the difference was significant (P<0.05). After recovery, the FA value in group A was (0.556±0.064) which was significantly higher than that in group B, which was statistically significant (P<0.05). Before recovery, the Fudl-Meyer score in group A were (85.162±9.861) points which were significantly higher than those in group B, and the difference was significant (P<0.05). The decreasing percentage of CST FA before and after rehabilitation was negatively correlated with increasing percentage of Fudl-Meyer score. Conclusion Magnetic resonance DTI technique can be used to evaluate the effect of limb motor rehabilitation training according to the extent of CST damage.

【关键词】脑梗死;磁共振;弥散张量 成像;皮质脊髓束;FA值;康复治疗

【中图分类号】R743

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2017.02.001

前言

脑梗死是临床常见的脑血管疾病之一,具有致死率高、致残率高 的特点。据调查,国内75%脑梗死患者会伴随不同程度的肢体功能障 碍,其中10%伴随严重残疾,直接影响着患者预后生活质量[1]。肢体功 能康复治疗是改善脑梗死后运动功能障碍的有效方式。磁共振扩散张 量成像(DTI)是一项新的磁共振成像技术,可显示活体白质纤维束变化 情况,便于临床了解皮质脊髓束(CST)受累情况,明确脑组织病变程 度。对此,本文分析了磁共振DTI在评估脑梗死康复治疗前后CST病变 程度及与康复治疗效果的应用情况,旨在探讨磁共振DWI的临床应用价 值,现报道如下。