目的 通过探究阿尔茨海默病 (AD)的ALFF值差异相关脑区的FA值，为AD 的早期诊断提供功能与分子影像学依据。 方法 采用西门子Trio 3.0T磁共振对17 例AD病人及17例对照组被试进行静息态 fmri、DTI检查。对静息态、DTI原始数据 进行预处理，得到ALFF图和FA图，并进行 组间独立双样本t检验，得到具有统计学 意义的差异脑区，做成mask用于FA图的统 计，然后进行组间独立样本t检验。结果 AD组和健康对照组相比，AD组患者ALFF值 在右侧后扣带回、双侧中央前回及左侧额 中回等脑区降低，在左侧丘脑、右侧海马 旁回及右侧颞上回等脑区增高，同时这些 脑区的FA值均增高。结论 阿尔茨海默病 患者与健康对照组相比，ALFF值异常的脑 区，如右侧后扣带回、左侧额中回、右侧 颞下回等默认网络脑区，FA值也同时存在 异常，说明AD患者功能存在异常的脑区的 微观结构也同时存在异常，这为早期客观 有效地诊断阿尔茨海默病提供了可能。

Objective To investigate reference criteria for early diagnostic of Alzheimer's disease by exploring the FA values of the related brain regions that their ALFF values are different. Methods 17 AD patients and 17 healthy man underwent rest state FMRI scans and DTI scans using Siemens Trio 3.0T MR scanner. ALFF maps and FA maps were obtained, first the ALFF maps of two groups were compared, then we take the result as the mask used for the comparison of the FA maps. Results The zones that the FA values of are abnormal is the same as the zones that ALFF are abnormal,at the same time,the FA values of AD are lower. Conclusion There were typical changes of FA and ALFF in AD patients, it may help the early diagnositic of AD.