目的 运用基于体素的形态测量 学(VBM)技术对颞叶癫痫(TLE)患者全脑白 质体积进行分析，并探讨颞叶癫痫患者 大脑内部的结构改变及其规律。方法 收 集22例颞叶癫痫患者(其中左侧颞叶癫痫 组11例，右侧颞叶癫痫组11例)和15例性 别、年龄匹配的正常健康志愿者，使用磁 化准备快速梯度回波序列(MPRAGE)进行全 脑结构像扫描，采用基于体素的形态学测 量学(VBM)方法对T1WI 3D图像进行统计 分析，计算每一组全脑白质的体积(以体 素表示)，提取部分脑区体积以比较组间 差异，另外分别将左TLE组、右TLE组与对 照组进行组间检验，以得出左TLE组与右 TLE组白质体积有差异的脑区。结果 1、 左TLE组较对照组脑白质体积降低的脑区 有：左侧海马旁回、右侧颞中回、左侧额 上回、左侧丘脑、右侧岛叶、左侧顶下小 叶、左侧顶上小叶；2、右TLE组较对照组 脑白质体积降低的脑区有：右侧颞下回、 左侧舌回、左侧枕中回、右侧额上回、左 侧中央前回、左侧颞上回、右侧楔前叶、 右侧中央后回、左侧顶下小叶。结论 颞 叶癫痫患者存在多个脑区白质结构异常， 通过采用基于体素的形态测量学技术可以 反映脑白质体积的变化。

Objective To investigate the white matter volume changes in patients with temporal lobe epilepsy (TLE) by using voxel-based morphometry (VBM) method. Methods A total of 22 patients with TLE (11 the left TLEs & 11 the right TLEs) and 15 gender, age and education-matched normal volunteers were enrolled in this study. Whole brain 3D structural images were acquired using magnetization prepared rapid acquisition gradient echo (MPRAGE) sequences were performed in all patients. 3DT1WI images were analyzed base on VBM methods and calculate of the brain white matter data expressing by voxel. Results Compared with healthy controls,the left TLE patients demonstrated significantly decreased regional cerebral in left para-hippocampal gyrus, right middles temporal gyrus, left superior frontal gyrus, left thalamus, right insular, left inferior parietal lobule and left superior parietal lobule. The right TLE patients demonstrated significantly decreased regional cerebral in right inferior temporal gyrus, left lingual gyrus, left middle occipital gyrus, right superior frontal gyrus, left precentral gyrus, left superior frontal gyrus, right precuneus, right postcentral gyrus and left inferior parietal lobule. Conclusion There are multiple brain white matter volumes reduction in patients with temporal lobe epilepsy, the VBM can reveal the volumes changes of white matter.