目的 探讨HIE患儿应用1 H-MRS联 合DTI诊断临床价值。方法 选取本院90 例HIE患儿作为本次研究观察组，另选取 同期正常分娩的90例健康新生儿为研究 对照组。两组均采用1 H-MRS及DTI扫描检 查，并比较两组影像学图像，测定两组 胆碱复合物(Cho)、N-乙酰基天门冬氨酸 (NAA)、肌酸复合物(Cr)、乳酸(LAC)、 肌醇(MI)、谷氨酸及谷氨酰胺(Glu-Gln) 等代谢产物，然后进行比较。结果 经检 查发现，其中对照组未见DTI异常信号； 观察组中，采用DTI检出HIE者为76例， 诊断准确率为84.4%明显高于普通MRI检 出39例，占43.3%，具有统计学意义，P ＜0.05。观察组患儿NAA/Cr明显低于对 照组，而Cho/Cr、MI/Cr及Clu+Cln/Cr、 Lac/Cr明显高于对照组，差异具有显著 性，P＜0.05。结论 临床应用DTI可于 HIE早期检测中有效显示其病灶范围及数 目，同时采用1 H-MRS可无创地测量患儿脑 部组织缺氧、缺血过程中所产生的代谢 产物，两者结合可提高患儿临床诊断准 确性，为患者预后评估提供有力价值。

Objective Discussion of HIE application 1 H-MRS joint DTI diagnostic clinical value. Methods Select the hospital 90 cases of HIE, as observed in this study group, select another period of 90 cases of normal deliveries healthy newborns in the control group for the study. Both groups were 1 H-MRS and DTI scans and radiographic images were compared, measured two choline (Cho), N-acetyl aspartate (NAA), creatine (Cr), lactate (LAC), myo-inositol (MI), glutamate and glutamine (Glu-Gln) and other metabolites, and then compared. Results The inspection found that one of the control group had no abnormal signal DTI, observation group, using DTI HIE were detected for 76 cases, 84.4% diagnostic accuracy was significantly higher than normal MRI detected in 39 cases (43.3%), a statistically significance, P<0.05. Observation group of children NAA/Cr was significantly lower than the control group, while Cho/Cr, MI/Cr and Clu+Cln/Cr, Lac/Cr was significantly higher, the difference was significant, P<0.05. Conclusion DTI may HIE clinical applications for early detection and effective display of its range and the number of lesions, while using 1 H-MRS can noninvasively measuring brain tissue hypoxia in children, metabolites produced during ischemia, a combination that can increase the risk of children clinical diagnostic accuracy for patients to provide strong prognostic value.