目的 评价18F-FDG PET/CT和增 强MSCT诊断胰腺癌的价值。方法 计算 机检索PubMed、EMBASE、The Cochrane library、Web of Science、中国生物医 学文献数据库、万方数字化期刊数据库和 中国期刊全文数据库等，检索时间截止 2015年3月。查找有关PET/CT及增强MSCT 对胰腺癌的诊断性试验。由2位评价员按 照纳入与排除标准独立筛选文献、提取资 料和评价纳入研究的方法学质量后，采用 Meta-Disc 1.4软件进行Meta分析。结果 最终纳入11篇文献，包括506例患者。以 手术或组织活检病理、临床及其他影像随 访为金标准，PET/CT和增强CT诊断胰腺癌 的合并敏感度、特异度及SROC曲线下面积 AUC值分别为0.93[95% CI(0.89,0.95)]、 0.76[95%CI(0.67,0.83)]、0.9149 和 0 . 8 0 [ 9 5 % C I ( 0 . 7 5 , 0 . 8 4 ) ]、 0 . 6 6 [95%CI(0.57,0.75)]、0.8159；PET/ CT结合增强CT的合并敏感度、特异度 及 S R O C曲线下面积 A U C值分别为 0 . 9 8 [ 9 5 % C I ( 0 . 9 4 , 0 . 9 9 ) ]、 0 . 9 0 [ 9 5 % C I (0.81,0.96)]、0.9873。结论 18F-FDG PET/CT诊断胰腺癌的敏感度较增强MSCT 高，特异度无显著差异，但将二者结合检 查可进一步提高诊断准确性。

Objective To evaluate the diagnostic performance of 18F-FDG PET/CT and contrast-enhanced multi-slice CT for pancreatic cancer. Methods Document retrieval was conducted on PubMed, EMbase, The Cochrane Library, Web of Science, CBM, WanFang Data and CNKI to retrieve the diagnostic studies about PET/CT and contrastenhanced multi-slice CT in the diagnosis of pancreatic cancer, the last retrieve time was March 2015. Two reviewers independently screened literature according to inclusion and exclusion criteria, extracted data, and assessed methodological quality of the included studies. Meta-analysis was then conducted using Meta-Disc 1.4 software. Results A total of eleven studies involving 509 patients met the eligible criteria. With the comparison of histopathology results (surgery or biopsy) or serial follow ups, which were considered as gold standard, the pooled sensitivity (SEN) and specificity (SPE), the area under (AUC) of the summary receiver-operating characteristic curve (SROC) were 0.93 [95%CI (0.89, 0.95)], 0.76[95%CI (0.67, 0.83)], 0.9149 and 0.80 [95%CI (0.75, 0.84)], 0.66 [95%CI (0.57, 0.75)], 0.8159 for PET/CT versus contrast-enhanced CT in diagnosing pancreatic cancer, respectively; the pooled SEN and SPE, the AUC value were 0.98 [95%CI (0.94, 0.99)], 0.90 [95%CI (0.81, 0.96)], 0.9873 for combining above two methods, respectively. Conclusion 18F-FDG PET/CT had a high sensitivity than contrast-enhanced multi-slice CT in diagnosing pancreatic cancer, the specificity was not significant difference, but both methods combination can further improve the diagnostic accuracy.