摘要
目的 探讨并总结Castleman 病 的临床及影像表现。方法 回顾性分析 我院2012年12月-2015年6月病理证实为 Castleman 病的8例患者的临床及影像资 料,并回顾相关文献,总结其临床及影像 学特征。6例进行CT平扫及增强扫描,1例 行CT平扫,1例行MRI平扫。结果 8例中, 男5例,女3例,年龄23-56岁,中位年龄 31.5岁。8例病理类型均为透明血管型, 均为单中心型。位于纵膈4例,右前胸壁 1例,腹膜后1例,盆腔2例CT平扫均表现 为单个类圆形或椭圆形的软组织肿块,边 界清晰,2例有散在斑点状钙化,1例有点 状钙化,1例有囊变坏死等特征;增强扫 描均表现为动脉期明显强化,并持续至静 脉期和延迟期,其中1例肿块周围或内部 可见增粗的血管影;MRI平扫T1WI为等信 号,T2WI为明显高信号。结论 Castleman 病较少见且易误诊,常表现为良性肿块特 征,部分病灶伴有钙化,了解其临床及影 像特征有助于检出本病。
Objective To explore and summarize the clinical and imaging manifestations of Castleman disease (CD). Methods Retrospective analysis the clinical and imaging data of 8 patients with pathologically proven CD from December 2012 to June 2015, and review the literature, summarize the clinical and imaging features. 6 cases CT scan and enhanced scan, 1 case CT scan, only 1 routine MRI scan. Results 5 cases were male in 8 cases, female 3 cases, aged 23 to 56 years old, with a median age of 31.5 years. Pathological type, 8 cases were transparent vascular , both for single center.4 cases were located in mediastinum, right front chest wall 1 case, retroperitoneal 1 case, 2 cases of pelvic cavity. CT scan performed a single round or oval mass, clear boundary, 2 cases had scattered punctate calcification, punctate calcification 1 case, 1 case has necrotic features. Enhanced scan were characterized obvious arterial enhancement, and continue to venous phase and delayed phase, including 1 case has enlarged blood vessels around the bump. MRI scan T1WI is equal signals, T2WI is obviously high signal. Conclusion CD is rare and easily misdiagnosed, often has benign tumor characteristics, some lesions with calcification, understanding the clinical and imaging features help to check out the disease.
【关键词】Castleman病;计算机断层扫 描;磁共振成像
【中图分类号】R734.5;R445.2
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2016.10.041
前言
巨淋巴结增生症(giant lymph node hyperplasia,GLNH)又名 Castleman病(Castleman disease, CD),1954年由Castleman等首次报 道而得名[1],本病较少见,以淋巴组织良性增生为特征,目前病因不 明,可能与慢性炎症刺激、免疫缺陷状态、自身免疫有关。也有研究 发现人类疱疹病毒8型和卡波西氏肉瘤相关疱疹病毒感染可能与多中心 型GLNH相关[2-3],白细胞介素-6、多功能的细胞因子[4]及血管内皮生长 因子的过度表达[5]也可能与本病的发生相关。GLNH临床表现多样,可发 生于多个部位,影像学表现缺乏特异性,较容易误诊。本研究通过回 顾性分析经病理证实的8例GLNH患者的临床及影像资料,并回顾相关文 献探讨其临床及影像表现特点。
中国CT和MRI杂志
第14卷, 第 10 期
2016年10月
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