Objective To investigate the clinical effects of chain process nursing management in emergency patients with severe trauma. Methods 142 patients with severe trauma treated by emergency department in our hospital from May 2015 to May 2016 were selected as the research objects, which were divided into observation group and control group by the random number table method with 71 cases in each group. The routine nursing was carried out in the control group, while the chain process nursing management were underwent in the observation group. The treatment effects of the two groups were observed and compared. Results The time of vital signs judgment, the general judgment and the basic life support rescue in the observation group were shorter than those of the control group, The success rate of observation group (92.96%) was higher than that of control group (81.69%), the differences were statistically significant (P<0.05). Conclusion The application of chain process nursing management in emergency rescue of patients with severe trauma can optimize the rescue procedure, improve the rescue efficiency, and reduce the mortality rate of patients; thus it is worthy to be promoted in the clinical.