Objective To analyze the effect of thoracoscopy combined with artificial pneumothorax in the treatment of myasthenia gravis(MG). Methods A total of 98 MG patients in our hospital were taken as the clinical research objects, and they were randomly divided into study group (49 cases) and control group(49 cases). Both groups were given conventional thoracoscopic surgery, besides, the study group was given additional artificial pneumothorax. The alleviating effects, visual field exposure, blood loss, operation time, hospital stay and complications in the two groups were compared. Results: The effective rate in the study group was 95.92% which was obviously higher than that in the control group 81.63%, and their difference was statistically significant(P<0.05), the complete exposure rate of visual field in the study group was 89.80% which was obviously better than that in the control group 59.18%, and their difference was statistically significant(P<0.05), the blood loss, operation time and hospital stay in the study group were all lower than those in the control group, and their differences were statistically significant(P<0.05), the incidence rate of complication in the study group was 2.04% which was obviously lower than that in the control group 14.29%, and their difference was statistically significant(P<0.05). Conclusion Thoracoscopy combined with artificial pneumothorax for MG patients can control complication rate, shorten operation time and hospital stay, and promote recovery. Thus, it is worthy of clinical application.