Objective To investigate the effect of low dose azithromycin on pulmonary tuberculosis complicated with bronchiectasis. Methods From September 2012 to September 2016, 90 patients with pulmonary tuberculosis and bronchiectasis were enrolled in our hospital. According to the random number table method, all patients were divided into two groups: observation group and control group, Patients in the acute late to oral low-dose azithromycin for 6 months, the control group of patients in the acute late to conventional treatment, not to give azithromycin, compared the two groups of patients with treatment results, the main comparison within 6 months of the number of retreatment, Serum high sensitive C-reactive protein (hs-CRP), white blood cell count (WBC) and lung function and other indicators of the changes. Results The number of re-treatment in the observation group was significantly lower than that in the control group at 6 months after treatment, and the improvement of hs-CRP, WBC and lung function were better than those of the control group, the difference was significant Statistical significance, P <0.05. Conclusion Long-term administration of low - dose azithromycin in patients with pulmonary tuberculosis complicated with bronchiectasis can significantly reduce the number of acute exacerbations and improve pulmonary function in patients with pulmonary tuberculosis, which is worthy of popularization and application.