Objective To study the clinical treatment effect of esomeprazole in bronchial asthma combined with gastroesophageal reflux disease (GERD). Methods From June 2015 to January 2016, 60 cases of asthma combined with GERD were selected as study objects, which were divided into observation group and control group with 30 cases in each group according to admission order number, observation group patients were given oral esomeprazole enteric-coated metformin hydrochloride, while the control group patients were given oral omeprazole enteric-coated metformin hydrochloride in six weeks treatment. The bronchial asthma score before and after treatment, gastroesophageal reflux disease score and clinical curative effect were observed and recorded. Results After the different treatments, the bronchial asthma score and gastroesophageal reflux disease score of observation group were lower than those of control group (2.00±0.50) point vs (3.00±0.70) point, (1.50±0.70) point vs (2.00±0.80) point, the total effective rate of observation group was significantly higher than that of control group(93.33% vs 66.67%) , the differences were statistical significant (P<0.05). Conclusion Esomeprazole has fewer complications and significant effect in the treatment of bronchial asthma combined with gastroesophageal reflux disease, which is worthy of clinical expansion.