Objective To study the effect of early nutrition support on the growth and neural development in very low birth weight infants (VLBWI). Methods From Jun. 2015 to Jun. 2016, a total of 94 VLBWI in our hospital were taken as the clinical research objects, and they were randomly divided into observation group and control group (47 cases in each group). The infants in control group were given traditional parenteral nutrition support, and the other infants in observation group were given early nutrition support. After nursing, the indexes such as neonatal body weigh decrease, birth weight recovery time, nutrition support time and hospital stay in these two groups were collected in order to evaluate their growth and development, and the neonatal behavior neurological assessment (NBNA) scores were also collected in order to evaluate their neural development. Results The neonatal body weigh decrease, birth weight recovery time, nutrition support time and hospital stay in the observation group were respectively lower than those in the control group, and the body weigh increase after birth weight recovery in the observation group was higher than that in the control group, the differences were statistical significance. There was no statistical significance in general reaction between groups (P>0.05). The scores of behavioral ability, passive muscular tension, active muscular tension and initial reflection in the observation group were respectively higher than those in the control group (P<0.05). Conclusion Early nutrition support has certain application value in clinic, which can significantly improve the growth and neural development of VLBWI.