Objective To study the transvaginal three-dimensional uterus fallopian tube ultrasonic angiography (3d-HyCOSy) role in infertility. Methods 66 cases of infertility patients according to the digital table method were randomly divided into 3 d - HyCOSy group and X-ray uterus oviduct imaging (HSG) group, 33 cases in each group, and its comparison with laparoscopy results analysis. Results 3 d-HyCOSy group 33 cases 66, tubal patency article 53 accounted for 80.30% (53/66), general and poor article 9 was 13.64% (9/66), blocking the four accounts for 6.06% (8/66). HSG group of 33 cases of tubal patency of article 66 of the article 37 accounted for 56.06% (37/66), flux and 14 accounted for 21.21% (14/66), blocking the article 15. 22.73% (15/66). After laparoscopic examination clew 3 d - HyCOSy groups were (80.41+2.4) %, (59.13+5.76) % for the HSG ones (P<0.05). Conclusion 3 d-HyCOSy diagnosis of infertility is a simple, effective and noninvasive, safe, accurate and repeatable, and the advantages of no radiation and does not affect the pregnancy, the uterine cavity lesions of uterus and fallopian tube patency of diagnosis and differential is superior to the traditional HSG.