Objective To evaluate the effect of cardiac rehabilitation nursing on cardiac function in patients with ST segment elevation myocardial infarction after percutaneous coronary intervention. Methods 80 patients with ST segment elevation myocardial infarction in our hospital during October 2015-October 2016 were selected as the research subject, which were divvied into group A (41 cases) and group B (39) according to the order of admission. Both patients in group A and B were treated with routine nursing, cardiac rehabilitation nursing were additionally underwent in group A, the LVEF level, ADL score, SAS score, six minutes walking distance and nursing satisfaction were compared between groups. Results LVEF level. ADL score, SAS score, six minutes walking distance of group A were better than those of group B respectively, [(55.02+6.08)% vs (46.14+5.31)%, (63.27+12.41) points vs (42.25+2.34) points, (36.14+5.24) points vs (58.34+7.62) points, (331.51+61.24) m vs (280.11+51.16) m], the differences were statistical significance (P<0.05). Patients nursing satisfaction of group A (97.56%) was better than that of group B (82.05%), the differences were statistical significance (P<0.05). Conclusion Cardiac rehabilitation nursing has a good effect in patients with ST segment elevation myocardial infarction after percutaneous coronary intervention, which can effectively improve the heart function of patients, is worthy of clinic application.